Variables | Dexmedetomidine group (n = 303) | Control group (n = 306) |
---|---|---|
Duration of anesthesia, mean (SD), h | 4.8 (1.8) | 4.9 (2.0) |
Duration of surgery, mean (SD), h | 3.6 (1.8) | 3.6 (1.8) |
Intraoperative drugs | ||
Study drug, median (IQR), ml | 30.0 (23.0, 38.0) | 29.0 (23.0, 38.0) |
Propofol, median (IQR), mg | 817 (600, 1102) | 960 (669, 1320) |
Sufentanil, median (IQR), μg | 72.0 (55.0, 93.0) | 78.5 (60.0, 106.0) |
Use of tropisetron, n (%) | 268 (88.4) | 263 (85.9) |
Use of NSAIDs, n (%) a | 11 (3.6) | 10 (3.3) |
Use of glucocorticoids, n (%) | 298 (98.3) | 297 (97.1) |
Low-dose glucocorticoids b | 295 (97.4) | 295 (96.4) |
High-dose methylprednisolone c | 3 (1.0) | 2 (0.7) |
Average BIS value, mean (SD) d | 50.5 (3.7) (n = 291) | 51.0 (4.9) (n = 294) |
Average MAP, mean (SD), mmHg | 79.3 (20.2) | 79.9 (22.0) |
Location of surgery, n (%) | ||
Intra-thoracic | 56 (18.5) | 53 (17.3) |
Intra-abdominal | 200 (66.0) | 221 (72.2) |
Spinal | 47 (15.5) | 32 (10.5) |
Type of surgery, n (%) | ||
Thoraco-laparoscopic | 230 (75.9) | 248 (81.0) |
Open thoraco-abdominal/spinal | 75 (24.1) | 58 (19.0) |
Total fluid infusion, median (IQR), ml e | 2300 (1700, 3100) | 2250 (1600, 3350) |
Allogenic red blood cells, n (%) | 20 (6.6) | 24 (7.8) |
Urine output, median (IQR), ml | 600 (300, 900) | 400 (250, 650) |
Estimated blood loss, median (IQR), ml | 100 (50, 300) | 100 (50, 300) |
No. of patients with complications, n (%) f | 72 (23.8) | 98 (32.0) |
Postoperative LOS, median (IQR), day | 8 (6, 12) | 8 (6, 11) |