From: Can perioperative hemodilution be monitored with non-invasive measurement of blood hemoglobin?
Study 1 | Study 2 | Study 3 | Study 4 | Study 5 | |
---|---|---|---|---|---|
Subjects | Volunteers | Volunteers | Before major surgery | During open cystectomy | Volunteers |
N | 10 | 10 | 10 | 23 | 10 |
Males / females | 10 / 0 | 10 / 0 | 7 / 3 | 19 / 4 | 7 / 3 |
Age, years | 22 (18–28) | 22 (19–37) | 64 (29–82) | 69 (67–75) | 33 (10) |
Body weight, kg | 79 (65–101) | 80 (75–100) | 79 (70–87) | 87 (64–90) | 77 (13) |
Infused | Ringer’s acetate | Ringer’s acetate | Ringer’s acetate | 20% albumin + Ringer’s lactate | Isotonic saline |
Amount, time | 20 mL/kg | 10 ml/kg | 5 mL/kg | 3 mL/kg + 2100 mL | 500 mL |
Infusion time (min) | 30 | 20 | 15 | 300 | 2–3 min |
Hemorrhage (mL) | 0 | 0 | 0 | 950 (700–1225) | 0 |
Sampling points (N) | 25 | 16 | 9 | 14 | 10 |
Duration (min) | 180 | 120 | 70 | 300 | 120 |
Reference | 11, 16 | 2, 12 | 13 | 14 | 15 |
Ethics approval, city | Stockholm, SE | Linköping, SE | Linköping, SE | Bern, CH | Linköping SE |
Ethics approval, Nr | 2009/1091–31/2 | M114–09 | 2011/101–31 | 2018–02351 | 2010/241–31 |
ClinicalTrials.gov | NCT01195025 | NCT01062776 | NCT01458678 | NCT03848507 | NCT01360333 |