Table 5 Comparisons of survived and death cases. Values are mean (SD), median (IQR [range]) or number (proportion)
From: Malignant hyperthermia when dantrolene is not readily available
| Â | Survived | Death | P value |
|---|---|---|---|
Age; y (n = 92) | 24.2 (16.7) | 23.1 (17.3) | 0.756 |
Sex; male (n = 92) | 40 (80.0%) | 32 (76.2%) | 0.659 |
Combined congenital disease (n = 92) | 21 (42.0%) | 22 (52.4%) | 0.32 |
First sign interval; h (n = 83) | 1.0 (0.2–2.8 [0–11.0]) | 1.5 (1.0–2.0 [0–18.0]) | 0.787 |
Maximum end-tidal PCO2; mmHg (n = 39) | 85.0 (71.8–101.3 [60.0–149.0]) | 91.0 (86.0–126.5 [75.0–223,0]) | 0.033 |
Maximum arterial PCO2; mmHg (n = 44) | 83.0 (73.9–99.4 [53.0–120.0]) | 101.0 (87.8–152.2 [52.8–250.0]) | 0.006 |
T first measured; °C (n = 64) | 38.5 (38.0–39.1 [35.8–43.0]) | 39.3 (38.6–41.1 [37.0–42.5]) | 0.012 |
Maximum T; °C (n = 88) | 40.3 (39.3–41.4 [38.3–44.5]) | 42.3 (42.0–43.1 [39.4–46]) | < 0.001 |
Maximum HR; bpm (n = 65) | 160.0 (140.0–180.0 [110.0–220.0]) | 160.0 (150.0–190.0 [120–230.0]) | 0.187 |
Generalised muscular rigidity (n = 92) | 29 (58.0%) | 31 (73.8%) | 0.113 |
Normal BP when first discovered (n = 92) | 18 (36.0%) | 8 (19.0%) | 0.072 |
Increased BP when first discovered (n = 92) | 1 (2.0%) | 5 (11.9%) | 0.055 |
No drop in BP when first discovered (n = 92) | 19 (38.0%) | 13 (31.0%) | 0.48 |
Cola-colored urine (n = 92) | 11 (22.0%) | 12 (28.6%) | 0.468 |
Oliguria or anuria (n = 92) | 9 (18.0%) | 13 (31.0%) | 0.147 |
Minimum pH (n = 48) | 7.14 (7.08–7.22 [6.81–7.40]) | 6.92 (6.79–7.05 [6.57–7.24]) | < 0.001 |
Potassium; mmol/L (n = 44) | 5.2 (4.6–5.7 [3.8–6.7]) | 7.1 (6.5–8.3 [5.7–10.1]) | < 0.001 |
Coagulation disorders (n = 92) | 11 (22.0%) | 19 (45.2%) | 0.018 |
Patient used sodium bicarbonate (n = 92) | 31 (62.0%) | 30 (71.4%) | 0.341 |
Patient used glucocorticoid (n = 92) | 35 (70.0%) | 31 (73.8%) | 0.686 |
Patient used active cooling (n = 92) | 42 (84.0%) | 30 (71.4%) | 0.145 |
Patient used furosemide (n = 92) | 32 (64.0%) | 17 (40.5%) | 0.024 |
Patient used mannitol (n = 92) | 12 (24.0%) | 3 (7.1%) | 0.029 |
Patient used blood purification treatment (n = 92) | 13 (26.0%) | 3 (7.1%) | 0.017 |
Clinical grading scale score; point (n = 82) | 58.0 (51.0–63.0 [33.0–73.0]) | 58.0 (51.0–61.0 [33.0–73.0]) | 0.809 |