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Table 2 CVVH setting, acid-base and metabolic control at CVVH start and end between groups

From: Feasibility and efficacy of modified fixed citrate concentration protocol using only commercial preparations in critically ill patients: a prospective cohort study with a historical control group

Variables

Fixed group

Titrated group

 

Start

End a

Start

End a

CVVH settings, mean (SD)

 Blood flow (ml/min)

122 (7)

122 (6)

123 (10)

122 (8)

 Citrate flow (ml/h)

261 (13) *

259 (13)

191(11)

242 (15)

 Replacement flow (ml/h)

2148 (102)

2218 (175)

2292 (122)

2198 (103)

 Total effluent flow (ml/h)

2743 (270)

2612(347)

2698 (470)

2745 (229)

 Sodium bicarbonate (ml/h)

70 (10) *

60 (25)

105 (25)

63 (23) **

 Calcium gluconate (ml/h)

9.5 (1.2) *

8.3 (2.7)

12.1 (1.2)

8.1 (3.4)

Acid-base status

 pH, mean (SD)

7.29 (0.1) **

7.39 (0.1)

7.26 (0.1) **

7.42 (0.2)

 Bicarbonate, mean (SD)

19.3 (4.1) **

25.5 (3.5) *

18.7 (3.5) **

27.9 (4.2)

 Base Excess, median (IQR)

−6.0 (−6.5, −5.4) **

1.7 (−0.5, 2.9) *

−5.7 (−6.7,− 5.3) **

4.1(− 0.7,4.7)

Metabolic control

 Serum creatinine, μmol/L

229 (169–559) **

136 (85–178)

240 (143–497) **

148 (93–185)

 Blood urea nitrogen, mmol/L

33.9 (15.6) **

22.1(9.8)

30.8 (14.7) **

20.3(6.7)

 Sodium, mmol/L

138.7 (3.5)

140.1 (5.7)

138.5(5.8)

141.0(5.2)

 Potassium, mmol/L

5.4 (1.8)**

3.9 (1.3)

5.3 (1.5) **

3.9 (1.3)

 Total serum calcium, mmol/L

2.12 (0.3)

2.10 (0.2)

2.13 (0.2)

2.12 (0.3)

 Ionized calcium, mmol/L

1.07 (0.15)

1.05 (0.14)

1.08 (0.13)

1.06 (0.08)

  1. Abbreviations: CVVH continuous veno-venous hemofiltration, IQR interquartile range, SD standard deviation
  2. *: p < 0.05 for fixed vs titrated group; **: p < 0.05 for CVVH start vs end in the each group
  3. a: The data at the end of CVVH comes from the average of the day