Variables | Fixed group | Titrated group | ||
---|---|---|---|---|
 | Start | End a | Start | End a |
CVVH settings, mean (SD) | ||||
 Blood flow (ml/min) | 122 (7) | 122 (6) | 123 (10) | 122 (8) |
 Citrate flow (ml/h) | 261 (13) * | 259 (13) | 191(11) | 242 (15) |
 Replacement flow (ml/h) | 2148 (102) | 2218 (175) | 2292 (122) | 2198 (103) |
 Total effluent flow (ml/h) | 2743 (270) | 2612(347) | 2698 (470) | 2745 (229) |
 Sodium bicarbonate (ml/h) | 70 (10) * | 60 (25) | 105 (25) | 63 (23) ** |
 Calcium gluconate (ml/h) | 9.5 (1.2) * | 8.3 (2.7) | 12.1 (1.2) | 8.1 (3.4) |
Acid-base status | ||||
 pH, mean (SD) | 7.29 (0.1) ** | 7.39 (0.1) | 7.26 (0.1) ** | 7.42 (0.2) |
 Bicarbonate, mean (SD) | 19.3 (4.1) ** | 25.5 (3.5) * | 18.7 (3.5) ** | 27.9 (4.2) |
 Base Excess, median (IQR) | −6.0 (−6.5, −5.4) ** | 1.7 (−0.5, 2.9) * | −5.7 (−6.7,− 5.3) ** | 4.1(− 0.7,4.7) |
Metabolic control | ||||
 Serum creatinine, μmol/L | 229 (169–559) ** | 136 (85–178) | 240 (143–497) ** | 148 (93–185) |
 Blood urea nitrogen, mmol/L | 33.9 (15.6) ** | 22.1(9.8) | 30.8 (14.7) ** | 20.3(6.7) |
 Sodium, mmol/L | 138.7 (3.5) | 140.1 (5.7) | 138.5(5.8) | 141.0(5.2) |
 Potassium, mmol/L | 5.4 (1.8)** | 3.9 (1.3) | 5.3 (1.5) ** | 3.9 (1.3) |
 Total serum calcium, mmol/L | 2.12 (0.3) | 2.10 (0.2) | 2.13 (0.2) | 2.12 (0.3) |
 Ionized calcium, mmol/L | 1.07 (0.15) | 1.05 (0.14) | 1.08 (0.13) | 1.06 (0.08) |