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Table 1 Up- and down-regulated metabolites between before anesthesia and 2 h after starting surgery in all patients

From: Effects of sevoflurane anesthesia and abdominal surgery on the systemic metabolome: a prospective observational study

Metabolites

Fold change

P-value

q-value

VIP

N-Acetyl-D-glucosamine 6-phosphate

6.581917

2.67E-14

4.98E-13

2.902062

AMP

4.707389

2.42E-13

3.68E-12

1.145699

Ephedrine

1.888023

0.000189

0.000568

1.898164

PC (15:0/20:0)

1.775193

0.001708

0.004864

1.232962

Sucrose

1.712725

3.36E-05

0.000114

1.409021

4-Ketocyclophosphamide

1.494188

0.007404

0.015887

2.021637

Acyclovir

1.402124

4.21E-07

1.92E-06

1.021479

Se-Methyl-L-selenocysteine

0.826514

0.000576

0.001884

2.999008

D-erythro-1-(Imidazol-4-yl) glycerol-3-phosphate

0.73012

1.66E-10

1.92E-09

1.236423

Citrate

0.381647

8.53E-07

4.95E-06

4.650407

4,6-Dichloro-3-methylcatechol

0.361359

4.00E-06

2.06E-05

1.123057

L-ribulose

0.333307

4.88E-12

5.66E-11

1.20026

cis-Aconitic acid

0.316411

1.42E-05

6.69E-05

1.128694

D-glucose

0.303546

5.18E-12

5.95E-11

6.04479

L-glutamine

0.225095

2.67E-10

2.44E-09

1.856811

L-selenocysteine

0.210814

1.33E-08

7.61E-08

2.994583

Pyroglutamic acid

0.150226

7.92E-05

0.063248

1.814755

Se-Methylselenomethionine

−5.14371

1.02E-18

3.19E-07

1.97583

Phenylethylamine

−1.99326

4.77E-26

5.97E-24

2.200773

Glycochenodeoxycholic acid

−1.42167

0.000184

0.000555

1.278177

5-Acetylamino-6-formylamino-3-methyluracil

−0.84274

4.91E-14

7.87E-13

1.313026

Cholesterol sulfate

−0.59075

9.72E-08

6.45E-07

1.349612

Bilirubin

−0.37302

0.000103

0.000417

1.323645

LysoPC (18:2(9Z,12Z))

−0.36135

8.93E-11

7.23E-10

12.17143

dTDP-3-methyl-4-oxo-2,6-dideoxy-L-allose

−0.31602

2.38E-07

1.13E-06

3.282894

Nicotine

−0.28852

1.49E-10

1.17E-09

3.286386

L-carnitine

−0.28411

1.25E-10

9.95E-10

11.95738

2-Oxoglutaramate

−0.25893

4.79E-05

0.000167

1.722153

Sphinganine

−0.23381

3.38E-10

2.54E-09

1.935018

4′-O-Demethylrebeccamyc

−0.16481

0.002641

0.007141

2.88872

  1. VIP Variable importance in the projection. Positive values in fold change indicate increases while negative values indicate decreases. q-value: False discovery rate adjusted p-values