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Fig. 1 | BMC Anesthesiology

Fig. 1

From: Anesthetics may modulate cancer surgical outcome: a possible role of miRNAs regulation

Fig. 1

Overview of mRNA regulation by miRNA. When some stimuli including anesthesia come to the cell nucleus, pre-miRNA is made from nucleus DNA by Drosha cleavage. Pre-miRNA is cleaved by Dicer/TRBP complex and becomes mature miRNA after miRNA/miRNA duplex. miRISC is formed by Ago1–4 binding to mature miRNA, out of which Ago2 is the essential for the target mRNA cleavage. Some miRISC can move out of the cells in MV or exocytosis in the endosome. miRISC inhibits its target mRNA expressions in three ways, depending on the sequence complementarity to the target mRNA sequence; mRNA cleavage with the subsequent RNA degradation occur in full complementarity, transcriptional repression or deadenylation in partial complementarity. The target protein expressions decrease due to mRNA inhibition by miRISC, leading to cell activity suppression. miRNA: micro RNA, Pri-miRNA: primary miRNA, Pre-miRNA: precursor miRNA, TRBP: transactivation response element RNA-binding protein, RISC: RNA-induced silencing complex, miRISC: miRNA-induced silencing complex, MV: microvesicle, mRNA: messenger RNA, CCR4-NOT: carbon catabolite repression-negative on TATA-less

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