| |
Intervention group (n = 72)
|
Control group (n = 72)
|
Relative risk or median difference (95% CI)a
|
P value
|
|---|
|
Primary endpoint
|
|
Acute kidney injury (ITT analysis)
|
9 (12.5%)
|
15 (20.8%)
|
RR = 0.60 (0.28–1.28)
|
0.180
|
|
Acute kidney injury (PP analysis)
|
9 (12.7%) (n = 71)
|
15 (21.1%) (n = 71)
|
RR = 0.60 (0.28–1.28)
|
0.179
|
|
Secondary endpoints
|
|
Acute kidney injury classification
| | | |
0.283
|
|
None
|
63 (87.5%)
|
57 (79.2%)
| | |
|
Stage 1
|
9 (12.5%)
|
12 (16.7%)
| | |
|
Stage 2
|
0 (0.0%)
|
2 (2.8%)
| | |
|
Stage 3
|
0 (0.0%)
|
1 (1.3%)
| | |
|
Complications within 30 days
|
4 (5.6%)
|
5 (6.9%)
|
RR = 0.80 (0.22–2.86)
|
> 0.999
|
|
Postoperative bleedingb
|
2 (2.8%)
|
1 (1.4%)
| | |
|
Acute coronary syndromec
|
1 (1.4%)
|
0 (0.0%)
| | |
|
Surgical infectiond
|
1 (1.4%)
|
4 (5.6%)
| | |
|
Length of hospital stay after surgery (day)
|
4 (4, 5)
|
4 (4, 5)
|
MD = 0.0 (0.0–0.0)
|
0.541
|
|
30-day mortality
|
0 (0.0%)
|
0 (0.0%)
|
–
|
> 0.999
|
|
6-month mortality
|
0 (0.0%)
|
1 (1.4%)
|
–
|
> 0.999
|
- Data are number (%), mean ± SD, or median (interquartile range)
- ITT intention-to treat, PP per-protocol
- aCalculated as the intervention group vs. or minus the control group
- bContinued decrease of hemoglobin level and required blood transfusion and/or transarterial embolization
- cNon-ST elevation myocardial infarction, diagnosed according to serum cardiac troponin I elevation and echocardiographic examination
- dFever > 38 °C, increased white blood cell count (> 12 × 109/L) and elevated inflammatory biomarkers necessitating upgrading antibiotic treatment
