Table 4 Pharmacokinetic variables: plasma concentrations (ng/ml) of chloroprocaine and CABA. Mean ± SD is shown; BLQL: below the quantification limit (4.0 ng/ml)
FAS | ||||||
|---|---|---|---|---|---|---|
Dose Group | Chloroprocaine 1% | CABA | ||||
30 mg | 40 mg | 50 mg | 30 mg | 40 mg | 50 mg | |
Pre-dose (0) | BLQL | BLQL | BLQL | BLQL | BLQL | BLQL |
5′ post-dose | BLQL | BLQL | BLQL | 16.13 ± 20.11 | 20.41 ± 23.04 | 24.89 ± 20.34 |
10′ post-dose | BLQL | BLQL | BLQL | 41.44 ± 31.78 | 38.85 ± 25.49 | 75. 83 ± 67.64 |
30′ post-dose | BLQL | BLQL | BLQL | 57.46 ± 43.77 | 67.18 ± 36.90 | 97.65 ± 61.70 |
60′ post-dose | BLQL | BLQL | BLQL | 47.02 ± 41.38 | 53.09 ± 31.80 | 78.38 ± 48.40 |