Sugammadex 2 mg/kg ABW N = 38 | Sugammadex 2 mg/kg IBW N = 38 | Sugammadex 4 mg/kg ABW N = 38 | Sugammadex 4 mg/kg IBW N = 36 | Neostigmine + Glycopyrrolate N = 38 | |
---|---|---|---|---|---|
n (%) | n (%) | n (%) | n (%) | n (%) | |
TREATMENT-EMERGENT EVENTS | |||||
Sinus Bradycardia | 2 (5.3) | 1 (2.6) | 2 (5.3) | 2 (5.6) | 1 (2.6) |
Sinus Tachycardia | 4 (10.5) | 3 (7.9) | 5 (13.2) | 1 (2.8) | 3 (7.9) |
Other Arrhythmias | 0 | 1 (2.6) | 0 | 0 | 1 (2.6) |
EVENTS OF CLINICAL INTEREST | |||||
Adjudicated Hypersensitivity | 0 | 0 | 0 | 1 (2.8) | 0 |
Adjudicated Anaphylaxis | 0 | 0 | 0 | 0 | 0 |
Clinically Relevant ↓ HR | 0 | 0 | 0 | 0 | 0 |
Clinically Relevant ↑ HR | 0 | 0 | 0 | 0 | 1 (2.6) |
Clinically Relevant Arrhythmia | 0 | 1 (2.6) | 1 (2.6) | 0 | 0 |
OTHER ADVERSE EVENTS | |||||
Drug-related Adverse Event | 0 | 2 (5.3) | 0 | 2 (5.6) | 6 (15.8) |
Serious Adverse Event | 1 (2.6) | 2 (5.3) | 0 | 3 (8.3) | 3 (7.9) |
Death | 0 | 0 | 0 | 0 | 1 (2.6) |