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Table 1 The characteristics of the included studies

From: Analgesic efficacy and safety of erector spinae plane block in breast cancer surgery: a systematic review and meta-analysis

author/year types of surgery Time of block No. type of block and local anaesthetic assessment of sensory Block intraoperative analgesia Postoperative analgesia Complications
Aksu 2019 [16] MRM; mastectomy+SLNB;
Lumpectomy+ ALND
Before induction of GA 25 ESPB group: 0.25% bupivacaine 20 ml (10 ml for each level) at bi-level (T2-T4) N fentanyl 2 mg/kg,
tramadol, paracetamol
morphine PCA Not reported
25 GA group: Received no intervention
Elsabeeny 2020 [17] MRM After induction of GA 25 ESPB group: 0.25% bupivacaine 25 mL at the T5 vertebral level N intravenous morphine 0.1 mg/kg. Ketorolac morphine prn Not reported
25 GA group: Received no intervention
Gürkan 2018 [18] MRM; mastectomy+SLNB;
Lumpectomy+ ALND
Before induction of GA 25 ESPB group: 0.25% bupivacaine 20 ml at the T4 vertebral level N fentanyl 2 mg/kg,
tramadol, paracetamol
morphine PCA Not reported
25 GA group: Received no intervention
Gürkan 2020 [19] MRM;Breast conserving surgery mastectomy Before induction of GA 25 ESPB group: 0.25% bupivacaine 20 ml at T4 vertebral level. N fentanyl 2 mg/kg,
tramadol, paracetamol
morphine PCA paracetamol 1 mg for every 6 h Not reported
25 GA group: Received no intervention
He
2020 [20]
MRM ± ALND Before induction of GA 20 ESPB group: 0.5%ropivacaine 20 ml at the vertebral T3 level N N/S Flurbiprofen axetil prn Not reported
20 GA group: Received no intervention
Li 2020 [21] MRM Before induction of GA 30 ESPB group: 0.25% bupivacaine 30 ml at T3-T5 vertebral level. N fentanyl morphine PCA Not reported
30 GA group: Received no intervention
Seelam 2020 [22] MRM Before induction of GA 50 ESPB group: 0.25% bupivacaine 30 ml T4 transverse process N fentanyl 1.5μg/kg Morphine prn paracetamol 1 g TID Not reported
50 GA group: Received no intervention
Sharma 2020 [23] total mastectomy + ALND Before induction of GA 30 ESPB group: 0.5%ropivacaine 20 ml, 0.4 mL/kg the T5 level Y fentanyl 1μg/kg,
diclofenac 1.5 mg/kg
morphine PCA paracetamol 1 g TID Not reported
30 GA group: Received no intervention
Singh 2019 [24] MRM Before induction of GA 20 ESPB group: 0.5% bupivacaine 20 ml at the T5 vertebral level Y morphine 0.1 mg/kg morphine PCA, diclofenac 1.5 mg/kg TID Not reported
20 GA group: Received no intervention
Wang 2019 [25] radical mastectomy Before induction of GA 50 ESPB group: 0.375%ropivacaine 20 ml at the T5 spinous process Y sufentanil 0.4 μg/kg Sufentanil PCA, Flurbiprofen axetil
prn
skin itch
50 GA group: Received no intervention
Yao
2019 [26]
MRM Before induction of GA 39 ESPB group: 0.5%ropivacaine 25 ml at the T4 spinous process N Sufentanil 0.5 μg/kg Sufentanil PCA flurbiprofen axetil 50 mg TID Not reported
40 GA group: 0.9% physiological saline 25 ml
  1. MRM: modified radical mastectomy; SLNB: sentinel lymph node biopsy; ALND: axillary lymph node dissection; N/S: not specified; N: no; Y: yes; PCA: patient-controlled analgesia; prn: as needed; ESPB: erector spinae plane block; GA: general anesthesia