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Table 3 Cardiovascular responses to norepinephrine in stroke volume responders and non-responders

From: Left ventricular-arterial coupling as a predictor of stroke volume response to norepinephrine in septic shock – a prospective cohort study

Variables

SV responders (n = 19)

SV non-responders (n = 15)

P value a

P value b

Before NE

After NE

Before NE

After NE

 

HR (beats/min)

112 ± 19

104 ± 20 c

106 ± 18

96 ± 21 c

0.384

0.255

SAP (mmHg)

84 ± 6

112 ± 14 d

81 ± 6

109 ± 11 d

0.247

0.456

DAP (mmHg)

48 ± 5

64 ± 9 d

47 ± 5

56 ± 5 d

0.535

0.006

MAP (mmHg)

60 ± 4

80 ± 9 d

59 ± 4

73 ± 5 d

0.269

0.027

CVP (mmHg)

9 ± 4

10 ± 3

8 ± 5

9 ± 3

0.498

0.329

VTI (cm)

16.9 ± 3.2

20.3 ± 3.3 d

20.3 ± 4.4

21.4 ± 4.1 c

0.012

0.380

SV (mL)

48 ± 10

58 ± 11 d

53 ± 12

56 ± 11 c

0.219

0.534

LVEDV (mL)

100 ± 12

104 ± 12 d

95 ± 13

98 ± 12 c

0.261

0.145

LVESV (mL)

52 ± 7

48 ± 6 d

43 ± 10

43 ± 9

0.004

0.061

LVEF (%)

47 ± 6

54 ± 6 d

54 ± 8

56 ± 8

0.006

0.255

Cardiac index (L/min/m2)

3.2 ± 0.9

3.6 ± 1.0 d

3.5 ± 0.8

3.3 ± 0.8

0.440

0.276

Tpre-e (ms)

61 ± 17

59 ± 14

53 ± 17

56 ± 14

0.145

0.587

Ttot-s (ms)

227 ± 45

246 ± 44 c

253 ± 40

280 ± 41 e

0.083

0.029

Ea (mmHg/mL)

1.62 ± 0.36

1.79 ± 0.42 c

1.43 ± 0.28

1.81 ± 0.40 d

0.092

0.877

Ees (mmHg/mL)

1.13 ± 0.24

1.50 ± 0.39 d

1.50 ± 0.46

1.82 ± 0.56 d

0.005

0.057

Ea/Ees ratio

1.47 ± 0.40

1.24 ± 0.32 d

1.02 ± 0.30

1.06 ± 0.34

0.001

0.145

  1. The data are presented as mean ± standard deviation
  2. a P value for comparisons of SV responders and non-responders before NE infusion; b P value for comparisons of SV responders and non-responders after NE infusion; c P < 0.01, d P < 0.001, and e P < 0.05 for comparisons of before and after NE infusion within group
  3. SV stroke volume; NE norepinephrine; HR heart rate; SAP systolic arterial pressure; DAP diastolic arterial pressure; MAP mean arterial pressure; CVP central venous pressure; VTI velocity-time integral; LVEDV left ventricular end-diastolic volume; LDESV left ventricular end-systolic volume; LVEF left ventricular ejection fraction; Tpre-e pre-ejection time; Ttot-s total systolic time; Ea effective arterial elastance; Ees left ventricular effective end-systolic elastance