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Table 1 Baseline demographic and clinical characteristics in the studied population group

From: Persistently higher serum sCD40L levels are associated with outcome in septic patients

 

Healty control

n = 6

SS

n = 19

SWS

n = 49

P

Sex (male/female)

3/3

12/7

34/15

0.586

Age (years)-median (p25-p75)

53.00 (42.25–62.00)

76.00 (71.00–81.00)

61.00 (45.00–73.00)

0.005

sCD40L(pg/ml)-median (p25-p75)

469.50 (406.83–547.36)

831.36 (526.58–981.72)

1022.68 (554.85–2215.13)

0.000

APACHE II score-median (p25-p75)

 

9.00 (7.00–11.00)

14.00 (11.00–16.00)

0.001

SOFA score-median (p25-p75)

 

1.00 (0.00–2.00)

8.00 (6.00–10.00)

0.000

ISTH score-median (p25-p75)

 

0.00 (0.00–2.00)

3.00 (2.50–4.50)

0.000

JAAM score-median (p25-p75)

 

1.00 (0.00–2.00)

4.00 (3.00–5.00)

0.000

PT-INR-median (p25-p75)

 

1.16 (1.12–1.34)

1.41 (1.21–1.66)

0.001

aPTT (seconds)-median (p25-p75)

 

41.10 (36.10–81.40)

49.40 (41.55–60.85)

0.080

Fibrinogen (g/L)-median (p25-p75)

 

3.10 (1.96–3.60)

3.94 (2.50–5.88)

0.022

FDP (ug/dl)-median (p25-p75)

 

5.46 (3.60–13.42)

21.81 (12.24–48.66)

0.000

D-Dimer (ug/ml)-median (p25-p75)

 

1.71 (0.80–3.58)

4.81 (3.24–10.11)

0.000

Platelet-median*103/mm3 (p25-p75)

 

157.00 (136.00–191.00)

136.00 (77.00–214.50)

0.305

Leukocytes-median*103/mm3 (p25-p75)

 

7.87 (5.28–11.90)

10.62 (7.50–15.44)

0.030

Lactate (mmol/L)-median (p25-p75)

 

1.50 (0.90–1.80)

2.00 (1.30–3.90)

0.006

28 days mortality (%)

 

0/19 (0)

20/49 (40.82)

0.000

Length of stay in the ICU (days)-median (p25-p75)

 

3.74 (3–5)

21.57 (13–28)

0.000

AKI-n (%)

 

0/19 (0)

16/49 (32.65)

0.000

Sepsis-induced liver injury-n (%)

 

0/19 (0)

3/49 (6.12)

0.277

ARDS-n (%)

 

0/19 (0)

21/49 (42.86)

0.000

PaO2/FiO2 ratio-median(p25-p75)

 

318.9 (300–330)

234.1 (170–300)

0.000

Subtotal gastrectomy-n(%)

 

3/19 (15.79)

10/49 (20.41)

0.549

Enteroanastomosis-n(%)

 

8/19 (42.11)

19/49 (38.77)

0.805

Cholecystectomy-n(%)

 

3/19 (15.79)

8/49 (16.33)

0.958

Choledocholithotomy-n(%)

 

5/19 (26.31)

12/49 (24.49)

0.878

  1. SWS Surgical patients without sepsis, SS Surgical sepsis patients, p 25–75 Percentile 25th–75th, APACHE II Acute Physiology and Chronic Health Evaluation II, SOFA Sepsis-related Organ Failure Assessment, ISTH International Society on Thrombosis and Haemostasis, JAAM Japanese Association for Acute Medicine, PT-INR Prothrombin time international normalized ratio, aPTT Activated partial thromboplastin time, FDP Fibrinogen degradation product, AKI Acute kidney injury, ARDS Acute respiratory distress syndrome, PaO2/FiO2 Pressure of arterial oxygen/fraction inspired oxygen