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Table 1 Comparisons of the clinical characteristics between survivors and non-survivors in the first 24 h

From: Association between normalized lactate load and mortality in patients with septic shock: an analysis of the MIMIC-III database

 

Survivors

(n = 826)

Non-survivors

(n = 545)

p value

Male

386 (46.7)

238 (43.7)

0.265

Age (years)

66.5 ± 16.3

69.2 ± 14.7

0.001

SOFA score

8 (5, 10)

10 (8, 13)

< 0.001

Comorbidities

 Obesity

51 (6.2)

28 (5.1)

0.420

 Congestive heart failure

277 (33.5)

192 (35.2)

0.518

 Cardiac arrhythmias

262 (31.7)

199 (36.5)

0.066

 Valvular disease

91 (11)

61 (11.2)

0.919

 Hypertension

139 (16.8)

101 (18.5)

0.416

 Chronic pulmonary disease

162 (19.6)

109 (20)

0.860

 Diabetes mellitus

282 (34.1)

182 (33.4)

0.775

 Hypothyroidism

103 (12.5)

68 (12.5)

0.997

 Liver disease

92 (11.1)

102 (18.7)

<  0.001

 AIDS

4 (0.5)

0 (0)

0.104

 Tumor

76 (9.2)

108 (19.8)

< 0.001

Laboratory results in the first 24 h

 Maximum anion gap (mmol/L)

18.9 ± 4.9

20.9 ± 6

< 0.001

 Maximum sodium (mmol/L)

141.3 ± 6.4

140.6 ± 6.4

0.036

 Maximum potassium (mmol/L)

4.8 ± 0.9

5.1 ± 1.1

< 0.001

 Maximum chloride (mmol/L)

110.6 ± 7.4

108.9 ± 8.1

< 0.001

 Maximum bilirubin (mg/L)

2.1 ± 4.2

3.9 ± 6.4

< 0.001

 Maximum creatinine (mg/dL)

2.2 ± 1.9

2.5 ± 1.7

0.002

 Maximum blood urea nitrogen (mg/dL)

39.4 ± 25.4

49.6 ± 30

< 0.001

 Maximum blood glucose (mg/dL)

206.6 ± 119.9

207.8 ± 112.3

0.853

 Minimum albumin (g/dL)

2.8 ± 0.7

2.5 ± 0.7

< 0.001

 Minimum hematocrit (%)

29 ± 5.4

28.2 ± 5.9

0.008

 Minimum hemoglobin (g/dL)

9.7 ± 1.8

9.3 ± 2

< 0.001

 Minimum platelet (K/uL)

186.3 ± 122.6

159 ± 121.7

< 0.001

 Maximum white blood cell count (K/uL)

19.8 ± 13.3

19.6 ± 23

0.835

 Maximum APTT (sec)

47.1 ± 28.3

57.3 ± 34.8

< 0.001

 Maximum INR (sec)

2 ± 1.5

2.5 ± 2.1

< 0.001

Lactate related variables

 Initial lactate (mmol/L)

2.8 ± 1.7

3.9 ± 2.9

< 0.001

 Maximum lactate (mmol/L)

4.3 ± 2.2

5.8 ± 3.8

< 0.001

 Lactate load (mmol·hr./L)

61.1 ± 36.4

94.3 ± 71.8

< 0.001

 Normalized lactate load (mmol/L)

2.5 ± 1.5

3.9 ± 3.0

< 0.001

  1. Data are presented as mean ± standard deviation or median (interquartile range) for continuous variables, and counts (percentages) for categorical variables
  2. AIDS acquired immunodeficiency syndrome, APTT activated partial thromboplastin time, INR international normalized ratio, SOFA sequential organ failure assessment