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Table 1 Coagulation proteins with correcting for hemodilution at different time points between the three groups

From: Comparison of the in-vivo effect of two tranexamic acid doses on fibrinolysis parameters in adults undergoing valvular cardiac surgery with cardiopulmonary bypass - a pilot investigation

 

Placebo group (n = 10)

Low dose group (n = 10)

High dose group (n = 10)

P-value

PAI-1 [mean (SD); ng/mL]

   

0.032

 T1

23.7 ± 2.5

22.9 ± 2.5

24.1 ± 2.2

 

 T2

28.2 ± 1.9

27.6 ± 2.8

28.4 ± 1.9

 

 T3

56 ± 5

50 ± 7a

57 ± 6

 

 T4

52 ± 6

45 ± 8a

51 ± 6

 

 T5

43.0 ± 2.2

39.6 ± 7.9

43.2 ± 4.5

 

TAFI [mean (SD); ng/mL]

   

0.046

 T1

17.5 ± 1.6

18.1 ± 1.1

16.4 ± 0.7

 

 T2

20.9 ± 1.7

21.8 ± 2.0

21.5 ± 1.6

 

 T3

43.0 ± 2.9

37.1 ± 4.4a

40.5 ± 5.2

 

 T4

37 ± 5

32 ± 6a

37 ± 5

 

 T5

33.5 ± 2.2

29.4 ± 4.1a

32.5 ± 3.6

 

PAP [mean (SD); ng/mL]

   

0.176

 T1

13.9 ± 1.9

15.8 ± 1.5

13.3 ± 2.1

 

 T2

19.7 ± 2.4

20.2 ± 2.3

19.7 ± 2.5

 

 T3

42 ± 4

39 ± 6

45 ± 8

 

 T4

37 ± 7

34 ± 7

39 ± 6

 

 T5

31 ± 6

28 ± 3

33 ± 5

 

tPA [mean (SD); ng/mL]

   

0.113

 T1

3.0 ± 0.3

3.5 ± 0.4

3.3 ± 0.6

 

 T2

3.67 ± 0.37

4.24 ± 0.55

4.17 ± 0.24

 

 T3

7.9 ± 1.2

7.5 ± 1.6

8.3 ± 1.1

 

 T4

6.6 ± 1.1

6.3 ± 1.0

7.2 ± 1.1

 

 T5

5.7 ± 1.1

5.6 ± 0.7

6.3 ± 0.9

 

TM [mean (SD); ng/mL]

   

0.019

 T1

1.33 ± 0.09

1.55 ± 0.15

1.57 ± 0.14

 

 T2

1.69 ± 0.16

1.65 ± 0.15

1.72 ± 0.18

 

 T3

3.5 ± 0.5

3.2 ± 0.5

3.7 ± 0.6

 

 T4

2.9 ± 0.4

2.6 ± 0.5

3.3 ± 0.7b

 

 T5

2.66 ± 0.48

2.24 ± 0.32

2.57 ± 0.28

 
  1. a: Low-dose group compared with placebo group;b: High-dose group compared with Low-dose group. PAI-1 Plasminogen activator inhibitor-1, TAFI Thrombin activatable fibrinolysis inhibitor, PAP Plasmin-antiplasmin complex, tPA Tissue plasminogen activator, TM Thrombomodulin. T1: per-operatively before TXA injection (baseline); T2: 5 min after TXA bolus administration (bolus); T3: 5 min after the onset of CPB (CPB); T4: 5 min before the end of CPB (End of CPB); T5: 5 min after protamine injection (protamine)