Single nucleotide polymorphisms associated with postoperative inadequate analgesia after single-port VATS in Chinese population

Table 1 Description of all single nucleotide polymorphisms analyzed

Gene	Polymorphism	Functional Consequence	Variant	Major/minor allele frequency	Hardy Weinberg p-value
ABCB1	rs1045642	Synonymous codon	A > G	0.62/0.38	0.37
ABCB1	rs1128503	Synonymous codon	A > G	0.67/0.33	0.63
ADRB1	rs1801252	Missense	A > G	0.83/0.17	0.46
ADRB1	rs1801253	Missense	G > C	0.74/0.26	1
CACNA1E	rs3845446	Intron variant	T > C	0.7/0.3	0.61
COMT	rs4633	Synonymous codon	C > T	0.72/0.28	0.86
COMT	rs4680	Missense	G > A	0.72/0.28	1
DRD2	rs6277	Synonymous codon	G > A	0.94/0.06	0.55
ESR1	rs9340799	Intron variant	A > G	0.81/0.19	0.25
KCNJ6	rs6517442	Upstream variant	C > T	0.73/0.27	0.07
KCNJ6	rs2070995	synonymous codon	T > C	0.61/0.39	0.55
OPRM1	rs1799971	Intron variant	A > G	0.69/0.31	0.50
	rs677830	Intron variant	C > T	0.89/0.11	0.46
	rs540825	Intron variant	A > T	0.92/0.08	1
P2RX7	rs7958311	Intron variant	G > A	0.52/0.48	0.67
P2RY12	rs3732765	Intron variant	G > A	0.87/0.13	1
SCN11A	rs33985936	Missense	C > T	0.89/0.11	0.48
SCN11A	rs11709492	Intron variant	C > T	0.74/0.26	0.71
SCN10A	rs6795970	Missense	A > G	0.86/0.14	0.38
SCN9A	rs6746030	Intron variant	A > G	0.95/0.05	0.36
	rs4286289	Intron variant	C > A	0.56/0.44	1
	3312G > T	Missense	G > T	0.9/0.1	0.69
TAOK3	rs795484	Intron variant	T > C	0.68/0.32	0.74
TAOK3	rs1277441	Intron variant	G > A	0.59/0.41	0.14
TGFB1	rs1800469	Downstream variant	A > G	0.51/0.49	0.26
TRPV1	rs8065080	Missense	T > C	0.64/0.36	0.22
UGT2B7	rs7439366	Missense	T > C	0.69/0.31	0.87
CREB1	rs2952768	None	T > C	0.57/0.43	0.77

Abbreviations: ABCB1 ATP binding cassette subfamily B member 1, ADRB1 adrenoceptor beta 1, CACNA1E calcium voltage-gated channel subunit alpha1 E, COMT catechol-O-methyltransferase, CREB1 cAMP responsive element binding protein 1, DRD2 dopamine receptor D2, ESR1 estrogen receptor 1, KCNJ6 potassium voltage-gated channel subfamily J member 6; OPRM1 opioid receptor mu 1, P2RX7 purinergic receptor P2X 7; P2RY12 purinergic receptor P2Y12, SCN11A sodium voltage-gated channel alpha subunit 11; SCN10A sodium voltage-gated channel alpha subunit 10, SCN9A sodium voltage-gated channel alpha subunit 9, TAOK3 TAO kinase 3, TGFB1 transforming growth factor beta 1, TRPV1 transient receptor potential cation channel subfamily V member 1, UGT2B7 UDP glucuronosyltransferase family 2 member B7

ISSN: 1471-2253