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Table 2 Studies characteristics

From: What is the role of locoregional anesthesia in breast surgery? A systematic literature review focused on pain intensity, opioid consumption, adverse events, and patient satisfaction

Author, year

Study

Sites

No.

Type of surgery

Anesthesia

Intervention

A. LUMPECTOMY/MASTECTOMY

Campbell et al.,[10] 2014

SB-RCT

New Zeland, 1

79

Lumpectomy/Mastectomy ± ALND

?

Local Infiltration

Couceiro et al.,[11] 2014

DB-RCT

Brazil, 1

44

Mastectomy

GA

IV lidocaine

Cros et al.,[12] 2018

DB-RCT

France, 1

Canada, 1

127

Lumpectomy/Mastectomy ± SLNB/ALND

GA

Pecs I

Ferreira Laso et al.,[13] 2014

DB-RCT

Spain, 1

73

Mastectomy

GA

Infusion pump

Gürkan et al.,[14] 2018

SB-RCT

Turkey,?

50

Lumpectomy/Mastectomy ± SLNB/ALND

GA

ESP

Ilfeld et al.,[15] 2014

DB-RCT

US,?

60

Mastectomy ± ALND

Sedation

PVB

Lanier et al .[16]2018

DB-RCT

US,?

45

Mastectomy + reconstruction ± SLNB/ALND

?

Intercostal + pectoral nerve blocks

Mohamed et al.,[17] 2013

DB-RCT

Egypt,?

140

Mastectomy ± ALND

GA

Local infiltration

Neethu et al.,[18] 2018

RCT

India, 1

60

Mastectomy ± SLNB/ALND

GA

Pecs I - II

Terkawi et al.,[19]2014

DB-RCT

US,?

71

Mastectomy

GA

IV lidocaine

Versyck et al.,[20] 2017

DB-RCT

Belgium, 1

140

Mastectomy/tumorectomy ±SLNB/ALND

GA

Pecs II

Wang et al.,[21] 2018

SB-RCT

China,?

64

Mastectomy + reconstruction ± ALND

GA

Pecs II

Wang et al.,[22] 2019

RCT

China,?

61

Mastectomy

GA

Pecs I + SPB

Yao et al.,[23] 2019

DB-RCT

China, 1

72

Mastectomy ± ALND

GA

SPB

B. BREAST AUGMENTATION

Gardiner et al.,[24] 2012

SB-RCT

Australia,?

40

BA

Sedation

PVB

Picard et al.,[25] 2017

SB-RCT

France,?

72

BA

?

Local infiltration

Schuitemaker et al.,[26] 2019

DB-RCT

Spain,?

30

BA

GA

Pecs II + SPB

C. BREAST REDUCTION

Christie et al., [27] 2017

DB-RCT

US, 1

40

BR

GA

Tumescent Anaesthesia

Valente et al.,[28] 2014

DB-RCT

Brazil,?

39

BR

GA

Local infiltration

  1. SB-RCT Single-Blind Randomized Controlled Trial, DB-RCT Double-Blind Randomized Controlled Trial, SLNB Sentinel Lymph Node Biopsy, ALND Axillary Lymph Node Dissection, GA General Anesthesia, Pecs Pectoralis nerve block, ESP Erector Spinae Plane block, PVB ParaVertebral Block, SPB Serratus Plane Block, BA Breast Augmentation, BR Breast Reduction;?, not reported