Table 3 Effect of baseline parameters on the evolution of MMSE scores
Variable | Coefficient (SE)* | P-value |
|---|---|---|
Age (years) | −0.071 (0.11) | 0.53 |
Gender (Male vs. Female) | 0.23 (1.41) | 0.87 |
BMI (kg/m2) | −0.077 (0.13) | 0.55 |
Education level(a) | 1.36 (0.72) | 0.069 |
No. of languages known | 1.44 (0.63) | 0.028 |
Working (Yes vs. No) | 2.95 (1.64) | 0.080 |
Marital status | ||
(Divorced vs Married) | −0.080 (1.75) | 0.96 |
(Widow vs. Married) | 0.65 (2.13) | 0.76 |
Self-sufficient (Yes vs. No) | 6.44 (2.31) | 0.0083 |
Living situation (No. of people) | 0.67 (1.10) | 0.55 |
Number of alcoholic drinks/week(b) | 0.48 (0.53) | 0.37 |
Smoking Status | ||
(Current vs. Never) | −0.38 (1.52) | 0.81 |
(Past vs. Never) | −3.50 (1.73) | 0.51 |
Surgery | ||
(Orthopedic vs. General) | 1.52 (1.76) | 0.39 |
(Genitourinary vs. General) | −0.95 (1.64) | 0.57 |
No. of psychoactive medications(b) | −0.91 (1.75) | 0.61 |
Type 2 Diabetes (Yes vs. No) | −2.82 (1.50) | 0.068 |
IPAQ work-related (h/week)(b) | 2.49 (1.40) | 0.084 |
IPAQ transport-related (h/day)(b) | 0.78 (1.45) | 0.59 |
IPAQ household-related (h/day)(b) | 1.00 (1.39) | 0.48 |
IPAQ leisure time-related (h/day)(b) | 3.32 (1.75) | 0.066 |
IPAQ sitting time (h/day)(b) | −1.75 (1.53) | 0.26 |
Energy (METs-min)(b) | 0.045 (0.083) | 0.59 |
GDS | −0.47 (0.14) | 0.0015 |
MMSE baseline | 0.92 (0.067) | < 0.0001 |
IL-6 baseline (pg/ml)(c) | −0.31 (0.46) | 0.50 |
IL-6 increase until 24 h (Yes vs. No) | 1.47 (1.56) | 0.35 |
HMGB1 baseline (pg/ml)(c) | 0.13 (0.46) | 0.77 |
HMGB1 increase until 24 h (Yes vs. No) | 0.13 (1.76) | 0.94 |