Table 3 In vivo progression of simvastatin treated and untreated MHS pigs during sevoflurane anesthesia
From: Impact of statin intake on malignant hyperthermia: an in vitro and in vivo swine study
Measurement | Threshold | Time (min) to reach thresholda | |
|---|---|---|---|
Statin (N = 4) | Untreated (N = 2) | ||
End tidal pCO2 | 50 mmHg | 19.6 (± 3.3) | 22.2 (± 3.5) |
Mean arterial pressure | 50 mmHg | 35.3 (± 7.9) | 38 (± 1.4) |
Core temperature | 40 °C | 47 (± 18.7) | 52.5 (± 9.2) |
Heart rate | Asystole | 62.7 (± 11.2) | 94.7 (± 44.5) |
Blood PaCO2 | 50 mmHg | 22.3 (± 4.8) | 30.5 (± 7.8) |
Blood pH | 7.2 | 29.8 (± 6.3) | 41 (± 7.1) |
Blood K+ | 6 mmol. L−1 | 41 (± 7.1) | 53.5 (± 10.6) |
Blood lactate | 10 mmol. L− 1 | 26 (± 7.1) | 38.5 (± 10.6) |