Study | Research aim | Surgical technique | Intervention | Infiltration locations | Result | Ref |
---|---|---|---|---|---|---|
Baudry [2008] | evaluate the effect of R wound infiltration | MRM or partial mastectomy with ALND | R: 4.75 mg/mL R 40 mL C: NS 40 mL | The wound | no differences | [12] |
Johansson [2003] | whether infiltration with R + fentanyl improves PP | Partial mastectomy with or without ALND | R1: 0.375% R R2: 0.375% R + Fentanyl 0.5 μg/kg C: Nil | The wound | no differences | [13] |
Johansson [2000] | whether infiltration with R improves PP | Partial mastectomy with or without ALND | R: R 3.75 mg/mL C: NS 0.3 mL/kg | The wound of breast and axilla | no differences | [14] |
Rica [2007] | if infiltration with R could improve PP | Mastectomy and ALND | R1: Preoperative 0.2% R 20 mL + NS to 80 mL R2: Postoperative 0.2% R 20 mL + NS to 80 mL | The wound | no differences | [15] |
Talbot [2004] | determine the influence of B irrigation on PP | MRM | B: 0.5% B 20 mL C: NS | Through the axillary drain into the axillary wound | no differences | [16] |
Nirmala [2019] | Whether wound instillation with B improve PP | MRM | R: 0.25% B 40 ml C: 40 ml normal saline | through chest and axillary drains into the wound | providing better analgesia within 15 h | [17] |
Vigneau [2011] | document the effect of R infiltration | Mastectomy or lumpectomy with ALND | R: R 7.5 mg/mL solution 20 mL C: NS 20 mL | The wound | PP was lower at 2, 4 and 6 h after surgery | [18] |
Albi-Feldzer [2013] | evaluate the influence of R wound infiltration | Conservative surgery with ALND, MRM with or without ALND | R: 0.375% R 3 mg/kg mixed with saline C: Saline solution | the wound, the 2nd & 3rd intercostal spaces and the humeral insertion of major pectoralis | decreased immediate PP (≤90 min) | [19] |