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Table 3 The ROC curve analysis of AChE, BuChE and ChAT showed that the activities and concentrations of AChE, BuChE and ChAT had high diagnostic value for POD, among which BuChE activity had the greatest diagnostic value, with all the AUCs greater than 0.5 and close to 1.0

From: Cerebrospinal fluid cholinergic biomarkers are associated with postoperative delirium in elderly patients undergoing Total hip/knee replacement: a prospective cohort study

CSF’s indexes

AUC

95% CI(L)

95% CI(U)

Youden’s index

Sensitivity

Specificity

AChE’s concentration (ng/ml)

0.803

0.763

0.839

0.4723

0.804

0.668

BuChE’s concentration (ng/ml)

0.882

0.848

0.910

0.6604

0.882

0.778

ChAT’s concentration (ng/ml)

0.885

0.852

0.913

0.6899

0.765

0.925

AChE’s activity (U/ml)

0.685

0.634

0.722

0.4728

0.628

0.845

BuChE’s activity(U/ml)

0.940

0.914

0.960

0.7947

0.902

0.893

ChAT’s activity (U/ml)

0.819

0.780

0.853

0.5250

0.784

0.741