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Table 3 The ROC curve analysis of AChE, BuChE and ChAT showed that the activities and concentrations of AChE, BuChE and ChAT had high diagnostic value for POD, among which BuChE activity had the greatest diagnostic value, with all the AUCs greater than 0.5 and close to 1.0

From: Cerebrospinal fluid cholinergic biomarkers are associated with postoperative delirium in elderly patients undergoing Total hip/knee replacement: a prospective cohort study

CSF’s indexes AUC 95% CI(L) 95% CI(U) Youden’s index Sensitivity Specificity
AChE’s concentration (ng/ml) 0.803 0.763 0.839 0.4723 0.804 0.668
BuChE’s concentration (ng/ml) 0.882 0.848 0.910 0.6604 0.882 0.778
ChAT’s concentration (ng/ml) 0.885 0.852 0.913 0.6899 0.765 0.925
AChE’s activity (U/ml) 0.685 0.634 0.722 0.4728 0.628 0.845
BuChE’s activity(U/ml) 0.940 0.914 0.960 0.7947 0.902 0.893
ChAT’s activity (U/ml) 0.819 0.780 0.853 0.5250 0.784 0.741