Table 2 Ongoing ClinicalTrial.gov registered trials regarding OLV during thoracic surgery
Title of trial | Location of trial | Interventions and outcome measures | ClinicalTrial.gov registration # |
|---|---|---|---|
Effect of Lung Protective One-lung Ventilation with Fix and Variable PEEP on Oxygenation and Outcome | Hungary, single center | Interventions Under tidal volume 6 mL/kg/PBW, compare fix 5 cmH2O PEEP and variable PEEP with recruitment maneuvers. Outcome Measures Primary: intraoperative oxygenation Secondary: postoperative complications and survival | NCT03968120 |
Optimal Level of PEEP in Protective One-lung Ventilation | Korea, single center | Interventions Under tidal volume 5 mL/kg/PBW, compare 3, 6, and 9 cmH2O PEEP and variable PEEP. Outcome Measures Primary: modified lung ultrasound score Secondary: intraoperative desaturation, PaO2/FiO2, plasma inflammatory cytokines, postoperative desaturation and pulmonary complication | NCT03856918 |
Electrical Impedance Tomography in One-Lung Ventilation | Chile, single center | Interventions Compare three tidal volumes (4, 6 and 8 mL/kg/PBW) and two PEEP’s (6 cmH20 and best PEEP obtained after a recruitment maneuver and decremental titration). Outcome Measures Ventilation/perfusion ratio, pulmonary mechanics, arterial gas measurement | NCT03728010 |
Individualized vs Low PEEP in One Lung Ventilation | US, single center | Interventions Compare individualized PEEP (max lung compliance) and low PEEP (5 cmH2O). Outcome Measures Primary: cerebral oximetry Secondary: arterial and venous blood oxygen tension, venous blood oxygen saturation, cardiac output, phenylephrine dose | NCT03569774 |
Individualized Perioperative Open-Lung Ventilatory Strategy During One-Lung Ventilation (iPROVE-OLV) | International, multicenter | Interventions Under tidal volume 5–6 mL/kg/PBW, compare alveolar recruitment maneuver plus PEEP titration trial and lung protective ventilation (PEEP 5 cmH2O). Outcome Measures Primary: postoperative pulmonary complications Secondary: postoperative complications, length of hospital stay | NCT03182062 |
Protective Ventilation with High Versus Low PEEP During One-lung Ventilation for Thoracic Surgery (PROTHOR) | International, multicenter | Interventions Under tidal volume 5 mL/kg/PBW, compare higher PEEP (PEEP 10 cmH2O + lung recruitment) and lower PEEP (PEEP 5 cmH2O only). Outcome Measures Primary: postoperative pulmonary complications | NCT02963025 |