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Table 2 Ongoing ClinicalTrial.gov registered trials regarding OLV during thoracic surgery

From: A nationwide survey of intraoperative management for one-lung ventilation in Taiwan: time to accountable for diversity in protective lung ventilation

Title of trial Location of trial Interventions and outcome measures ClinicalTrial.gov registration #
Effect of Lung Protective One-lung Ventilation with Fix and Variable PEEP on Oxygenation and Outcome Hungary, single center Interventions
Under tidal volume 6 mL/kg/PBW, compare fix 5 cmH2O PEEP and variable PEEP with recruitment maneuvers.
Outcome Measures
Primary: intraoperative oxygenation
Secondary: postoperative complications and survival
NCT03968120
Optimal Level of PEEP in Protective One-lung Ventilation Korea, single center Interventions
Under tidal volume 5 mL/kg/PBW, compare 3, 6, and 9 cmH2O PEEP and variable PEEP.
Outcome Measures
Primary: modified lung ultrasound score
Secondary: intraoperative desaturation, PaO2/FiO2, plasma inflammatory cytokines, postoperative desaturation and pulmonary complication
NCT03856918
Electrical Impedance Tomography in One-Lung Ventilation Chile, single center Interventions
Compare three tidal volumes (4, 6 and 8 mL/kg/PBW) and two PEEP’s (6 cmH20 and best PEEP obtained after a recruitment maneuver and decremental titration).
Outcome Measures
Ventilation/perfusion ratio, pulmonary mechanics, arterial gas measurement
NCT03728010
Individualized vs Low PEEP in One Lung Ventilation US, single center Interventions
Compare individualized PEEP (max lung compliance) and low PEEP (5 cmH2O).
Outcome Measures
Primary: cerebral oximetry
Secondary: arterial and venous blood oxygen tension, venous blood oxygen saturation, cardiac output, phenylephrine dose
NCT03569774
Individualized Perioperative Open-Lung Ventilatory Strategy During One-Lung Ventilation (iPROVE-OLV) International, multicenter Interventions
Under tidal volume 5–6 mL/kg/PBW, compare alveolar recruitment maneuver plus PEEP titration trial and lung protective ventilation (PEEP 5 cmH2O).
Outcome Measures
Primary: postoperative pulmonary complications
Secondary: postoperative complications, length of hospital stay
NCT03182062
Protective Ventilation with High Versus Low PEEP During One-lung Ventilation for Thoracic Surgery (PROTHOR) International, multicenter Interventions
Under tidal volume 5 mL/kg/PBW, compare higher PEEP (PEEP 10 cmH2O + lung recruitment) and lower PEEP (PEEP 5 cmH2O only).
Outcome Measures
Primary: postoperative pulmonary complications
NCT02963025
  1. PaO2/FiO2 Partial pressure of arterial oxygen/fraction of inspired oxygen ratio, PBW Predicted body weight, PEEP Positive end-expiratory pressure, OLV One-lung ventilation