Fig. 5

Effect of dexmedetomidine and propofol on CMMCs in endotoxemic mice. n = 4 per group. Typical spatiotemporal maps showed CMMCs in endotoxemic mice receiving 10% fat emulsion, propofol, saline, and dexmedetomidine 15 mins and 24 h after treatment in a-d and e-h respectively. The ordinate represents time, and the abscissa is indicative of spatial location from the oral end (O) to the anal end (A). The width of the gut (mm), representative of contractions, was pseudocolored. i-k. dexmedetomidine not propofol increased CMMCs frequency, shortened percentage of the length of propagation and slowed down velocity of propagation 15 mins after injection. Dexmedetomidine had no effect on CMMCs 24 h after injection. Data were expressed as median and interquartile ranges and analysed by one-way ANOVA. ^*P < 0.05, LPS + DEX vs LPS + NS. LPS, lipopolysaccharide. FE, fat emulsion. PPF, propofol. NS, normal saline. DEX, dexmedetomidine. CMMCs, colonic migrating motor complexes