Fig. 2
Depth of sedation and vital signs of endotoxemic mice after administration of propofol or dexmedetomidine. n = 6 per group. a. Does-dependent sedative depth of endotoxemic mice accepting 40 μg·kg− 1 and 80 μg·kg− 1 dexmedetomidine. b. Does-dependent sedative depth of endotoxemic mice accepting 40 mg.kg− 1 and 50 mg.kg− 1 propofol. c-f. The mice with administration of 40 mg·kg− 1 propofol and 80 μg·kg− 1 dexmedetomidine had similar pulse oxygen saturation percentage, respiratory rate, and systolic blood pressure over time while dexmedetomidine strikingly decreased heart rate. Vital signs were recorded from 5 mins to 40 mins after sedation. Data were expressed as mean ± SD and analysed by two-way repeated-measures ANOVA. *P < 0.05, ***P < 0.001, LPS + 80 μg·kg− 1 DEX vs LPS + 40 mg·kg−1PPF. LPS, lipopolysaccharide. PPF, propofol. DEX, dexmedetomidine