Table 4 Postoperative outcomes of patients receiving intrathecal morphine (ITM) or Usual care. Data presented as median (interquartile range) or number of patients (proportion)
ITM (n = 125) | Usual care (n = 91) | P-value | |
|---|---|---|---|
Time in the intensive care unit (hours) | 17 (12:21.5) | 10 (0:18) | 0.0001 |
Time to full ward diet (hours) | 79 (54.5:116.8) | 73.75 (50.75:102.8) | 0.41 |
Time to first oral opioid use (days) | 2 (2:3) | 2 (1:3) | 0.98 |
Patients with at least one complication | 88 (70.4%) | 67 (73.6%) | 0.65 |
NUMBER OF COMPLICATIONS | |||
0 | 37 (29.6%) | 24 (27.0%) | 0.90 |
1 | 31 (24.8%) | 25 (28.1%) | |
2 | 16 (12.8%) | 11 (12.4%) | |
3 | 9 (7.2%) | 9 (10.1%) | |
≥4 | 32 (25.6%) | 20 (22.5%) | |
WORST CLAVIEN-DINDO GRADE OF COMPLICATIONS | |||
I | 26 (29.5%) | 22 (33.8%) | 0.13 |
II | 51 (58.0%) | 28 (43.1%) | |
III | 5 (5.7%) | 8 (12.3%) | |
IV | 4 (4.5%) | 7 (10.8%) | |
V | 2 (2.3%) | 0 (0%) | |
Respiratory depression requiring naloxone | 1 (0.8%) | 1 (1.1%) | > 0.99 |
Nausea or vomiting requiring anti-emetics | 101 (80.8%) | 72 (79.1%) | 0.86 |
Pruritis requiring treatment with antihistamine, 5-hydroxytryptamine or dopamine receptor antagonist, or opiate-antagonist | 17 (13.6%) | 9 (9.9%) | 0.53 |
SEVERE SEDATION | |||
POD 0 | 36/125 (28.8%) | 38/90 (42.2%) | 0.04 |
POD 1 | 19/122 (15.6%) | 13/87 (14.9%) | 0.99 |
POD 2 | 5/107 (4.7%) | 9/75 (12.0%) | 0.09 |
POD 3 | 1/25 (4%) | 3/55 (5.5%) | 0.99 |
Length of stay (days) | 6 (5:10) | 7 (5:10) | 0.69 |
30-day readmission | 11 (8.8%) | 9 (9.9%) | 0.82 |
Time in the intensive care unit (hours) | 17 (12:21.5) | 10 (0:18) | 0.0001 |
Time to full ward diet (hours) | 79 (54.5:116.8) | 73.75 (50.75:102.8) | 0.41 |
Time to first oral opioid use (days) | 2 (2:3) | 2 (1:3) | 0.98 |
Patients with at least one complication | 88 (70.4%) | 67 (73.6%) | 0.65 |