ITM (n = 125) | Usual care (n = 91) | P-value | |
---|---|---|---|
Age (years) | 61 (52.5:68.5) | 59 (49:66) | 0.26 |
Gender (male: female) | 81 (65%): 44 (35%) | 45 (49%): 46 (51%) | 0.03 |
Body mass index (kg/m2) | 25.9 (22.8:30.6) | 26.2 (23.4:30.1) | 0.71 |
Charlson comorbidity index | 6.5 (4.0:8.0) | 7.0 (4.0:8.0)i | 0.99 |
Preoperative chemotherapy within 3 months | 21 (16.8%) | 11 (12.1%) | 0.44 |
AMERICAN SOCIETY OF ANAESTHESIOLOGISTS SCORE | |||
1 | 1 (0.8%) | 2 (2.2%) | 0.72 |
2 | 44 (35.2%) | 35 (38.5%) | |
3 | 77 (61.6%) | 51 (56%) | |
4 | 3 (2.4%) | 3 (3.3%) | |
BASELINE BIOCHEMISTRY | |||
Haemoglobin (g/L) | 143 (129.5:150.5) | 131 (122:146) | 0.005 |
White cell count (× 109/L) | 7 (5:8) | 6 (5:8) | 0.05 |
Platelet count (× 109/L) | 220 (158:273.3) | 222 (173.5:280) | 0.52 |
Urea (mg/dL) | 6 (4.5:7) | 6 (4:7) | 0.53 |
Creatinine (μmol/L) | 76.5 (63.25:87) | 71.5 (61.25:88) | 0.34 |
Estimated glomerular filtration rate (mL/min/1.73m2) | 86 (75:90) | 90 (74.5:90) | 0.6 |
Alanine transaminase (U/L) | 49 (33.5:97) | 57.5 (41.5:88.25) | 0.67 |
Aspartate transaminase (U/L) | 53 (47:85.5) | 68 (64:113) | 0.24 |
Alkaline phosphatase (U/L) | 147 (94:201.5) | 176 (19.3:246.5) | 0.33 |
Gamma-glutamyltransferase (U/L) | 109 (65.75:157.5) | 125 (72.5:220) | 0.72 |
Albumin (g/L) | 39 (35:42) | 37.5 (34:39) | 0.08 |
Bilirubin (μmol/L) | 11.5 (6.25:16.75) | 12 (7.5:21) | 0.54 |
Activated partial thromboplastin time (s) | 27 (24:29) | 28 (25:30) | 0.17 |
International normalized ratio | 1 (1:1) | 1 (1:1) | 0.4 |
PATHOLOGY | |||
Benign | 13 (10.4%) | 20 (21.9%) | 0.17 |
Adenoma | 8 (6.4%) | 8 (8.8%) | |
Haemangioma | 1 (0.8%) | 2 (2.2%) | |
Other liver pathology | 4 (3.2%) | 10 (11.0%) | |
Malignant | 112 (89.6%) | 71 (78.1%) | |
Hepatocellular carcinoma | 36 (28.8%) | 29 (31.9%) | |
Cholangiocarcinoma | 14 (11.2%) | 5 (5.5%) | |
Gallbladder tumor | 4 (3.2%) | 2 (2.2%) | |
Metastatic colorectal | 58 (46.4%) | 35 (38.5%) | |
COMPLEXITY OF RESECTION | |||
Minor resection (≤ 3 sections) | 85 (68.0%) | 68 (74.7%) | 0.29 |
Major resection (≥ 4 sections) | 40 (32.0%) | 23 (25.3%) | |
TYPE OF SURGERY | |||
Right hepatectomy | 23 (18.4%) | 12 (13.2%) | 0.53 |
Left hepatectomy | 9 (7.2%) | 8 (8.8%) | |
Central hepatectomy | 2 (1.6%) | 0 (0%) | |
Segmental resection (< 3 segments) | 76 (60.8%) | 61 (67.0%) | |
Extended left or right hepatectomy (> 5+ segments) | 15 (12%) | 10 (11.0%) |