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Table 1 Characteristics of the studies included in the meta-analysis

From: Dezocine prevents sufentanil-induced cough during general anesthesia induction: a meta-analysis of randomised controlled trials

Study

Country

Study type

Opioid

Opioid injection dose and time

Group

Weight (kg)

Age (years)

Gender

M: F

ASA

I/II

Intervention

Time 1

Time 2

Li et al., 2017 [10]

China

RCT

sufentanil

0.3 μg /kg, 5 s

Dezocine

62.2 ± 11.9

42.8 ± 11.5

80 (47/33)

55 /25

0.1 mg/kg, intravenous

10 min

2 min

Placebo

64.1 ± 13.8

43.5 ± 10.4

80 (45/35)

56 /24

equal volume of 0.9% saline

10 min

2 min

Sun et al., 2015 [11]

China

RCT

sufentanil

0.5 μg/kg, 3 ~ 5 s

Dezocine

58 ± 9

51 ± 10

80 (36/44)

50 /30

0.1 mg/kg, 3 ~ 5 s, intravenous

3 min

2 min

Placebo

59 ± 9

50 ± 9

80 (41/39)

55 /25

equal volume of 0.9% saline

3 min

2 min

Wang et al., 2015 [17]

China

RCT

sufentanil

0.3 μg /kg, 5 s

Dezocine

NP

NP

NP

NP

0.1 mg/kg, intravenous

10 min

2 min

Placebo

NP

NP

NP

NP

equal volume of 0.9% saline

10 min

2 min

Liu et al., 2015 [6]

China

RCT

sufentanil

0.5 μg/kg, 3 s

Dezocine

62 ± 9

52 ± 13

185 (91/94)

125/60

0.1 mg/kg, 3 ~ 5 s, intravenous

2 min

2 min

Placebo

60 ± 8

53 ± 11

185 (99/86)

117/68

equal volume of 0.9% saline

2 min

2 min

Xu et al., 2014 [18]

China

RCT

sufentanil

0.5 μg/kg, 3 s

Dezocine

61.2 ± 10.9

41.2 ± 14.3

50 (26/24)

NP

0.1 mg/kg, intravenous

5 min

2 min

Placebo

62.1 ± 9.7

39.7 ± 16.1

50 (23/27)

NP

equal volume of 0.9% saline

5 min

2 min

  1. RCT randomised controlled trial, M male, F female, ASA American Society of Anesthesiologists, NP not provided, Time 1 record the time of intervention earlier than anesthesia induction, Time 2 start recording the time of coughing after opioid injection