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Table 4 Association between intraoperative hyper−/hypotension and postoperative complications

From: Intraoperative hypotension is associated with increased postoperative complications in patients undergoing surgery for pheochromocytoma-paraganglioma: a retrospective cohort study

Thresholds and durationsNUnivariate analysisMultivariate analysis a
OR (95% CI)P valueOR (adjusted CI)P value
SBP ≥200 mmHg  (95% CI), P < 0.05
  ≥ 1 min971.485 (0.760–2.902)0.2471.094 (0.497–2.407)0.824
SBP ≥180 mmHg  (98.3% CI), P < 0.017 (0.05/3) b
  ≥ 1 min1861.185 (0.616–2.281)0.6110.735 (0.275–1.966)0.455
  ≥ 5 min991.130 (0.569–2.246)0.7270.719 (0.268–1.930)0.425
  ≥ 10 min631.321 (0.613–2.847)0.4780.792 (0.259–2.424)0.619
SBP ≥160 mmHg  (99% CI), P < 0.01 (0.05/5) b
  ≥ 1 min2701.099 (0.463–2.611)0.8310.753 (0.175–3.240)0.617
  ≥ 5 min2131.655 (0.801–3.423)0.1740.963 (0.308–3.016)0.933
  ≥ 10 min1611.217 (0.640–2.314)0.5500.702 (0.254–1.940)0.370
  ≥ 20 min922.043 (1.055–3.958)0.0341.142 (0.406–3.213)0.740
  ≥ 30 min532.294 (1.090–4.828)0.0291.234 (0.387–3.933)0.641
SBP ≤100 mmHg  (99.3% CI), P < 0.007 (0.05/7) b
  ≥ 1 min2784.065 (0.950–17.390)0.0593.141 (0.338–29.226)0.166
  ≥ 5 min2432.335 (0.948–5.749)0.0651.710 (0.416–7.037)0.306
  ≥ 10 min2112.685 (1.201–6.002)0.0161.839 (0.511–6.617)0.200
  ≥ 20 min1623.017 (1.489–6.113)0.0021.809 (0.573–5.714)0.164
  ≥ 30 min1213.043 (1.547–5.882)0.0011.871 (0.603–5.801)0.136
  ≥ 40 min834.293 (2.211–8.336)< 0.0012.535 (0.796–8.076)0.030
  ≥ 50 min584.392 (2.199–8.774)< 0.0012.625 (0.828–8.320)0.024
SBP ≤95 mmHg  (99% CI), P < 0.01 (0.05/5) b
  ≥ 1 min2452.253 (0.915–5.551)0.0771.746 (0.446–6.834)0.293
  ≥ 5 min2172.452 (1.096–5.487)0.0291.807 (0.528–6.180)0.215
  ≥ 10 min1702.695 (1.330–5.458)0.0061.916 (0.640–5.735)0.126
  ≥ 20 min1063.900 (2.008–7.547)< 0.0013.211 (1.081–9.536)0.006
  ≥ 30 min634.874 (2.465–9.634)< 0.0013.173 (1.012–9.950)0.009
SBP ≤90 mmHg  (98.8% CI), P < 0.012 (0.05/4) b
  ≥ 1 min2072.424 (1.120–5.248)0.0251.653 (0.510–5.358)0.283
  ≥ 5 min1472.588 (1.324–5.058)0.0051.662 (0.579–4.769)0.226
  ≥ 10 min1013.396 (1.762–6.546)< 0.0012.160 (0.757–6.159)0.065
  ≥ 20 min535.122 (2.540–10.332)< 0.0013.680 (1.107–12.240)0.006
SBP ≤85 mmHg  (98.3% CI), P < 0.017 (0.05/3) b
  ≥ 1 min1533.021 (1.512–6.033)0.0021.855 (0.647–5.317)0.161
  ≥ 5 min933.516 (1.822–6.783)< 0.0012.039 (0.739–5.621)0.094
  ≥ 10 min604.692 (2.361–9.325)< 0.0013.975 (1.321–11.961)0.003
SBP ≤80 mmHg  (95% CI), P < 0.05
  ≥ 1 min985.062 (2.580–9.935)< 0.0013.465 (1.484–8.093)0.004
  1. N Number, SBP Systolic blood pressure, OR Odds ratio, CI Confidence interval
  2. a Independent factors with P values < 0.10 in univariate analyses or were considered clinically important were included in the multivariate logistic regression model. These included male gender, ASA classification (3 + 4 vs. 1 + 2), maximal tumor diameter (cm), paraganglioma, preoperative combined antihypertensives, period of surgery, type of anesthesia (combined epidural-general vs. general), duration of surgery (min), type of surgery (open vs. laparoscopic/transurethral), intraoperative blood transfusion, combined antihypertensives during surgery and use of vasopressors during surgery. History of diabetes mellitus and previous stroke were excluded due to correlation with ASA classification; preoperative calcium channel blocker, SBP, DBP and HR were excluded due to correlation with preoperative combined antihypertensives; duration of anesthesia and intraoperative positive fluid balance were excluded due to correlation with duration of surgery; intraoperative minimal hemoglobin and estimated blood loss were excluded due to correlation with intraoperative blood transfusion; use of antihypertensives during surgery was excluded due to correlation with combined antihypertensives during surgery; use of combined vasopressors during surgery were excluded due to correlation with use of vasopressors during surgery
  3. b The threshold level of significance was corrected using the Bonferroni method