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Table 4 Association between intraoperative hyper−/hypotension and postoperative complications

From: Intraoperative hypotension is associated with increased postoperative complications in patients undergoing surgery for pheochromocytoma-paraganglioma: a retrospective cohort study

Thresholds and durations

N

Univariate analysis

Multivariate analysis a

OR (95% CI)

P value

OR (adjusted CI)

P value

SBP ≥200 mmHg

  

(95% CI), P < 0.05

  ≥ 1 min

97

1.485 (0.760–2.902)

0.247

1.094 (0.497–2.407)

0.824

SBP ≥180 mmHg

  

(98.3% CI), P < 0.017 (0.05/3) b

  ≥ 1 min

186

1.185 (0.616–2.281)

0.611

0.735 (0.275–1.966)

0.455

  ≥ 5 min

99

1.130 (0.569–2.246)

0.727

0.719 (0.268–1.930)

0.425

  ≥ 10 min

63

1.321 (0.613–2.847)

0.478

0.792 (0.259–2.424)

0.619

SBP ≥160 mmHg

  

(99% CI), P < 0.01 (0.05/5) b

  ≥ 1 min

270

1.099 (0.463–2.611)

0.831

0.753 (0.175–3.240)

0.617

  ≥ 5 min

213

1.655 (0.801–3.423)

0.174

0.963 (0.308–3.016)

0.933

  ≥ 10 min

161

1.217 (0.640–2.314)

0.550

0.702 (0.254–1.940)

0.370

  ≥ 20 min

92

2.043 (1.055–3.958)

0.034

1.142 (0.406–3.213)

0.740

  ≥ 30 min

53

2.294 (1.090–4.828)

0.029

1.234 (0.387–3.933)

0.641

SBP ≤100 mmHg

  

(99.3% CI), P < 0.007 (0.05/7) b

  ≥ 1 min

278

4.065 (0.950–17.390)

0.059

3.141 (0.338–29.226)

0.166

  ≥ 5 min

243

2.335 (0.948–5.749)

0.065

1.710 (0.416–7.037)

0.306

  ≥ 10 min

211

2.685 (1.201–6.002)

0.016

1.839 (0.511–6.617)

0.200

  ≥ 20 min

162

3.017 (1.489–6.113)

0.002

1.809 (0.573–5.714)

0.164

  ≥ 30 min

121

3.043 (1.547–5.882)

0.001

1.871 (0.603–5.801)

0.136

  ≥ 40 min

83

4.293 (2.211–8.336)

< 0.001

2.535 (0.796–8.076)

0.030

  ≥ 50 min

58

4.392 (2.199–8.774)

< 0.001

2.625 (0.828–8.320)

0.024

SBP ≤95 mmHg

  

(99% CI), P < 0.01 (0.05/5) b

  ≥ 1 min

245

2.253 (0.915–5.551)

0.077

1.746 (0.446–6.834)

0.293

  ≥ 5 min

217

2.452 (1.096–5.487)

0.029

1.807 (0.528–6.180)

0.215

  ≥ 10 min

170

2.695 (1.330–5.458)

0.006

1.916 (0.640–5.735)

0.126

  ≥ 20 min

106

3.900 (2.008–7.547)

< 0.001

3.211 (1.081–9.536)

0.006

  ≥ 30 min

63

4.874 (2.465–9.634)

< 0.001

3.173 (1.012–9.950)

0.009

SBP ≤90 mmHg

  

(98.8% CI), P < 0.012 (0.05/4) b

  ≥ 1 min

207

2.424 (1.120–5.248)

0.025

1.653 (0.510–5.358)

0.283

  ≥ 5 min

147

2.588 (1.324–5.058)

0.005

1.662 (0.579–4.769)

0.226

  ≥ 10 min

101

3.396 (1.762–6.546)

< 0.001

2.160 (0.757–6.159)

0.065

  ≥ 20 min

53

5.122 (2.540–10.332)

< 0.001

3.680 (1.107–12.240)

0.006

SBP ≤85 mmHg

  

(98.3% CI), P < 0.017 (0.05/3) b

  ≥ 1 min

153

3.021 (1.512–6.033)

0.002

1.855 (0.647–5.317)

0.161

  ≥ 5 min

93

3.516 (1.822–6.783)

< 0.001

2.039 (0.739–5.621)

0.094

  ≥ 10 min

60

4.692 (2.361–9.325)

< 0.001

3.975 (1.321–11.961)

0.003

SBP ≤80 mmHg

  

(95% CI), P < 0.05

  ≥ 1 min

98

5.062 (2.580–9.935)

< 0.001

3.465 (1.484–8.093)

0.004

  1. N Number, SBP Systolic blood pressure, OR Odds ratio, CI Confidence interval
  2. a Independent factors with P values < 0.10 in univariate analyses or were considered clinically important were included in the multivariate logistic regression model. These included male gender, ASA classification (3 + 4 vs. 1 + 2), maximal tumor diameter (cm), paraganglioma, preoperative combined antihypertensives, period of surgery, type of anesthesia (combined epidural-general vs. general), duration of surgery (min), type of surgery (open vs. laparoscopic/transurethral), intraoperative blood transfusion, combined antihypertensives during surgery and use of vasopressors during surgery. History of diabetes mellitus and previous stroke were excluded due to correlation with ASA classification; preoperative calcium channel blocker, SBP, DBP and HR were excluded due to correlation with preoperative combined antihypertensives; duration of anesthesia and intraoperative positive fluid balance were excluded due to correlation with duration of surgery; intraoperative minimal hemoglobin and estimated blood loss were excluded due to correlation with intraoperative blood transfusion; use of antihypertensives during surgery was excluded due to correlation with combined antihypertensives during surgery; use of combined vasopressors during surgery were excluded due to correlation with use of vasopressors during surgery
  3. b The threshold level of significance was corrected using the Bonferroni method
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