Intraoperative hypotension is associated with shortened overall survival after lung cancer surgery

BMC Anesthesiology

Table 4 Association between different combinations of intraoperative hyper−/hypotension and duration of overall survival

Conditions	N	Unadjusted ^a		Adjusted ^a,b
Conditions	N	Hazard ratio (95% CI)	p value	Hazard ratio (95% CI)	p value
Intraoperative hypertension (+), hypotension (−) ^c	167	Ref.		Ref.
Intraoperative hypertension (+), hypotension (+) ^c	119	1.116 (0.789–1.579)	0.534	1.033 (0.709–1.507)	0.864
Intraoperative hypertension (−), hypotension (−) ^c	69	1.198 (0.797–1.800)	0.384	0.952 (0.608–1.489)	0.829
Intraoperative hypertension (−), hypotension (+) ^c	160	1.746 (1.290–2.364)	< 0.001	1.736 (1.218–2.475)	0.002

Abbreviations: N number of patients with events, CI confidence interval
^a Performed with COX proportional-hazards regression analyses
^b Adjusted for age, body mass index, male gender, chronic smoking, history of hypertension, preoperative chemotherapy, perioperative sufentanil equivalent, perioperative dexamethasone, perioperative flurbiprofen axetil, intraoperative blood transfusion, conservative resection/biopsy (vs. other types of surgery), mediastinal lymph node dissection, small cell lung cancer, tumor differentiation, pathological Tumor-Node-Metastasis stage, occurrence of postoperative complications, and postoperative chemo−/radiotherapy. Maximal tumor size was excluded due to correlation with pathological Tumor-Node-Metastasis stage
^c Intraoperative hypertension was defined as a systolic blood pressure > 140 mmHg for ≥5 min; intraoperative hypotension was defined as a systolic blood pressure < 100 mmHg for ≥5 min

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