Table 1 Patient characteristics in Mean (SD) or n (%) at baseline and measurements during surgery
Baseline characteristics | With Ce (n = 186) | Without Ce (n = 14) |
|---|---|---|
Before surgery | ||
Age | 81.9 (7.8) | 79.8 (7.0) |
Mini-Mental Status Examination (MMSE) | 24.2 (3.7) | 25.1 (3.4) |
Geriatric depression scale score | 3.9 (3.6) | 3.0 (2.0) |
Clinical Dementia Rating (n = 184/14) | ||
0 | 75 (41%) | 7 (50%) |
0.5 | 88 (48%) | 6 (43%) |
≥ 1.0 | 21 (11%) | 1 (7%) |
Charlson Comorbidity Score | 1.5 (1.7) | 2.0 (2.4) |
0 | 66 (35%) | 6 (43%) |
1 | 83 (45%) | 3 (21%) |
2 | 26 (14%) | 3 (21%) |
> 2 | 11 (6%) | 2 (14%) |
Alzheimer’s cerebrospinal fluid biomarkers | ||
Total Tau, pg/ml (n = 164/6) | 490.8 (275.1) | 617.7 (435.7) |
Phosphorylated Tau (pg/ml (n = 163/6) | 56.7 (25.1) | 63.0 (32.9) |
Amyloid Beta 42 (pg/ml (n = 164/6) | 298.3 (164.1) | 281.2 (106.7) |
Amyloid Beta 42/Total Tau(n = 164/6) | 0.71 (0.38) | 0.61 (0.32) |
Amyloid Beta 42/Phosphorylated Tau (n = 163/6) | 5.75 (2.83) | 5.16 (2.29) |
During surgery | ||
Observers Assessment Alertness/Sedation score | 2.2 (2.1) | 1.4 (2.1) |
Bispectral Index number (n = 183/13) | 69.1 (18.1) | 75.0 (13.7) |
Brain Effect Site Concentration, ug/ml | 1.26 (0.79) | --- (−--) |
Mean Arterial Pressure | 73.4 (10.5) | 77.1 (11.8) |