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Table 3 Inclusion and exclusion criteria and baseline characteristics of participants

From: Efficacy and safety of pulsed radiofrequency as a method of dorsal root ganglia stimulation for treatment of non-neuropathic pain: a systematic review

ID

Inclusion criteria / Previous treatment

Exclusion criteria

Baseline characteristics

Low back pain

Holanda 2016 [14]

- low back pain for > 3 months

- cancer in lumbar region

- coagulation disturbance

- infection

- neurologic deficits

PRF treatment group:

- 2 males, 9 females

- age range: 42–86 years

- pain duration range: 3–144 months

Lidocaine injection group:

- 3 males, 4 females

- age range: 33–82 years

- pain duration range: 3–48 months

Laser treatment group:

- 3 males, 7 females

- age range: 35–84 years

- pain duration range: 14–120 months

Lee 2018 [15]

- age 20 years or older

- predominantly axial low back pain for > 3 months

- medication therapy for > 3 months without benefit

- physical rehabilitation for > 3 months without benefit

- an identified etiology of low back pain (i.e., grade II or III spondylolisthesis)

- positive response to previous spine interventions such as epidural steroids or sacroiliac joint blocks

- previous facet interventions, lumbar spine fusion

- untreated coagulopathy

- concomitant medical (e.g., unstable angina or degenerative osteoarthritis of knee), or psychiatric

conditions

- concurrent lumbar pain generator (i.e., muscular/fascial pain, or organs within the

abdominal cavity) that could confound the diagnosis of low back pain

TFESI DRG block + PRF treatment group:

- median age: 74 years, range 53–90 years

- median duration of symptoms: 26 months, range: 3–58 months

PRF treatment alone group:

- median age: 75 years, range 33–93 years

- median duration of symptoms: 25 months, range: 3–125 months

Yang 2010 [16]

- chronic LBP with focal neurologic symptoms for > 3 months

- spinal disorders

- coagulopathy

- concomitant medical or psychiatric illness

PaMNI group:

- 5 males, 11 females

- mean age: 55.5 ± 13.9 years

Fluoroscopy group:

- 2 males, 11 females

- mean age: 57.2 ± 14.7 years

Hsu 2017 [17]

- age 20 years or older

- LBP for > 6 months that worsened upon prolonged sitting or standing

- failed to improve after at least 3 months of conservative treatment

- sagittal imbalance

- spinal listhesis

- infection

- tumor

- stenosis

- disc herniation causing nerve root compression

- 29 males, 55 females

- mean age: 56.03 ± 9.04 years

Tsou 2010 [18]

- chronic LBP with or without lower-limb pain for > 6 months

- conservative treatment for > 3 months without benefit

- participants with symptoms of nerve root compromise due to mild or moderate bulging disc also included

Not given

LBP without lower limb pain group:

- 26 males, 23 females

- men age: 62.94 ± 12.39 years

- level treated: L2: 49

LBP with lower limb pain group:

- 33 males, 45 females

- men age: 63.88 ± 14.00 years

- levels treated: L2: 78, L3: 14, L4: 33, L5: 72, S1: 21

Postsurgical pain

Albayrak 2017 [19]

- VAS score of ≥3 during activity

- pain lasting for ≥2 months

- no improvement with physical medicine and rehabilitation

- refractory to pharmacological therapies including paracetamol 2 g/day and the maximum tolerable dose of nonsteroidal anti-inflammatory drugs for 1 week and pregabalin 300 mg/day for 2 weeks

- any pathological features, such as acute strain or sprain

- stroke/central nervous system disease

- serious psychiatric disorders

- sciatic pain

- fibromyalgia

- mental impairment affecting ability to understand tests/measures

PRF + TENS + exercise group:

- 2 (9.1%) males, 20 (90.9%) females

- mean age: 62.1 ± 4.9 years

TENS + exercise group:

- 2 males (11.8%), 15 (88.2%) females

- mean age: 65.8 ± 6.5 years

Cohen 2006 [20]

- age 18 years or older

- duration of pain ≥3 months

- VAS score ≥ 5

- pain deemed to be of neuropathic origin based on history and physical examination

- presence of pathology that could account for a majority of persistent symptoms (e.g. recurrent cancer)

- untreated coagulopathy

- unstable medical or psychiatric condition

PRF treatment group:

- 6 males, 7 females

- mean age: 45.8 ± 4.7 years

Intercostal nerve stimulation:

- 7 males, 8 females

- mean age: 50.8 ± 4.0 years

Medical management group:

- 9 males, 12 females

- mean age: 48.6 ± 2.4 years

Fam 2018 [21]

- between 18 and 65 years

- refractory to morphine sulfate (MST) and pregabalin

- bleeding tendency

- local infection at the site of the intervention

- psychological disorders

- disturbed anatomy (congenital, traumatic, and postsurgical)

- allergy to used medication (local anesthetics and contrast)

- inability to lie comfortably during the intervention as the cardiopulmonary distress

Not given

Pain associated with herpes zoster

Kim 2017 [6]

- participants who underwent the procedure between 30 and 180 days after zoster onset

- trigeminal-nerve-involved zoster

- follow-up loss within 6 months after the procedure

- participants who did not receive appropriate antiviral treatment during the acute phase of herpes zoster

- cases where both procedures were performed between 30 and 180 days of zoster onset

PRF treatment group:

- 11 males, 9 females

- mean age: 68.10 ± 7.99 years

- days from zoster onset: 68.20 ± 40.53

Continuous epidural block group:

- 6 males, 16 females

- mean age: 70.41 ± 10.25 years

- days from zoster onset: 74.09 ± 44.50

Cervicogenic headache

van Zundert 2003 [22]

- 18 years or older

- chronic pain in the cervical region

for > 6 months

- pharmacotherapy, physical or manual therapy, TENS, and/or rehabilitation program without benefit

- temporary pain relief of at least 50% on 7-point Likert scale after a diagnostic segmental nerve block

- ability to understand the information provided

- informed consent

- systemic disease

- tumor

- clinically demonstrable neurologic deficit

- signs of radicular compression

- 5 males, 13 females

- age range: 27–77 years

- duration of pain prior to treatment: <  1–40 years

- DRG level treated: C2: 4, C3: 2, C4: 2, C5: 4, C6: 3, C7: 3

Zhang 2011 [23]

- initial diagnostic selective the greater occipital nerve blocks with 1.5% lidocaine

- pain relief of 90% or more lasting for at least 30 min.

NA

Patient 1:

- 40-years-old woman

- pain lasting for 5 years

Patient 2:

- 66-years-old women

- pain lasting for 1 year

Complex regional pain syndrome

Albayrak 2016 [24]

- no improvement with the combined use of medical therapy, physical therapy, and the rehabilitation program

NA

Patient 1:

- 69-years-old women

- 9 months of previous pain

Patient 2:

- 48-years-old women

Apiliogullari 2015 [25]

NA

NA

16-years-old girl

Intractable vertebral metastatic pain

Arai 2015 [26]

- confirmed to have vertebral metastases by bone scintigraphy, computed tomography, and magnetic resonance imaging

- systemic analgesics did not provide a sound pain relief

- neurological deficit

- coagulopathy

- significant cardiovascular disease

- 9 males, 6 females

- age range: 34–82 years

Scrotal and inguinal pain

Hofmeester 2013 [27]

- an orchidopexy performed

- test block of the relevant DRG with 1 ml of levobupivacaine 0.25%

NA

- 13-years-old boy

Occipital radiating pain in rheumatoid arthritis

Lee 2015 [28]

- right 3rd occipital and right 4th,

- 5th, and 6th cervical medial branch blocks with levobupivacaine (0.3 mL; 0.75%) and triamcinolone (1 mg) were injected at each level

NA

- 74-years-old female

- pain lasting for 2–3 years

Chronic migraine

Li 2018 [29]

- failure of pharmacological therapy and stellate ganglion block

- diagnostic C2 block with 1 mL of 2% lidocaine with 75–100% pain relief for only 4 days

NA

- 34-years-old female

- 10 years of chronic migraine

  1. Abbreviations: DRG dorsal root ganglion, LBP low back pain, NA not applicable, PaMNI system patient-mount navigated intervention, PRF pulsed radiofrequency, RF radiofrequency, TENS transcutaneous electrical nerve stimulation, TFESI transforaminal epidural steroid injection, VAS visual analogue scale