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Table 2 Ventilator settings, blood gas analysis, and hemodynamic parameters before, 2 and 24 h after pECLA initiation

From: Validation of RESP and PRESERVE score for ARDS patients with pumpless extracorporeal lung assist (pECLA)

 

Before pECLA

2 h after pECLA start

24 h after pECLA start

Ventilation

all (n = 73)

survivor (n = 37)

non-survivor(n = 36)

all (n = 73)

survivor (n = 37)

non-survivor (n = 36)

all (n = 73)

survivor (n = 37)

non-survivor (n = 36)

peak pressure, mbar

32.7+/− 6.2

32.6+/−7.0

32.6+/− 5.2

30.4+/− 5.4*

31.4+/− 6.1

30.4+/− 4.5*

29.4+/− 4.3

29.1+/− 4.4

29.9+/− 4.3

plateau pressure, mbar

32.7+/−6.2

32.6+/− 7.0

32.6+/− 5.2

30.4+/− 5.4*

31.4+/− 6.1

30.4+/− 4.5*

29.4+/− 4.3

29.1+/− 4.4

29.9+/− 4.3

PEEP, mbar

13.7+/− 4.1

13.6+/− 5.2

12.8+/− 4.7

14.4+/− 3.8

14.9+/− 4.2

13.3+/− 4.6

13.7+/− 3.9

13.7+/− 5.1

12.9+/− 4.7

driving pressure, mbar

19.0+/− 5.6

18.7+/− 6.4

19.0+/− 4.6

16.2+/− 4.6*

16.4+/− 5.1*

16.3+/− 4.4*

15.5+/− 4.2

15.8+/− 4.7

16.2+/− 4.3

TV per kg bodyweight, ml/kg

4.8+/−1.6

4.3+/−2.0

4.5+/− 1.6

4.1+/− 1.2*

3.8+/− 1.3

3.8+/− 0.8*

4.4+/− 1.5

4.3+/− 1.7

3.7+/− 1.2

Blood gas analysis

 pH

7.23+/− 0.14

7.24+/− 0.14

7.21+/− 0.15

7.37+/− 0.12*

7.39+/− 0.12*

7.35+/− 0.12*

7.40+/− 0.10†

7.42+/− 0.08

7.37+/− 0.10

 PaCO2, mmHg

79.4+/−30.6

74.6+/− 25.7

85.9+/− 34.9

51.7+/− 11.0*

49.9+/− 10.4*

53.7+/− 11.5*

48.6+/− 11.6†

45.1+/− 11.4†‡

50.9+/− 13.8†‡

 SaO2, %

94.6+/−4.8

94.4+/− 5.7

94.6+/−3.6

95.6+/− 3.1

95.1+/− 6.6

94.9+/− 2.2

96.3+/− 2.4†

96.6+/− 2.1

95.8+/− 2.7

 PaO2/FIO2, mmHg

126+/− 59

132 +/− 75

124+/− 47

107+/− 59*

123+/− 73*

90+/− 30*

136+/− 54

151+/− 49†‡

120+/− 54

Hemodynamics

 heart rate, bpm

103+/− 22

100+/− 23

104+/− 23

96+/− 21

95+/− 21

99+/− 22

92+/− 19

93+/− 19

91+/− 20

 MAP, mmHg

76+/− 14

76+/− 11

77+/− 13

80+/− 14*

81+/− 8*

80+/− 13

83+/− 13

83+/− 13

83+/− 14

 CVP, mmHg

16+/− 5

15+/− 4

16+/− 5

15+/− 5

14+/− 5

16+/− 6

14+/− 4

15+/− 4

14+/−5

 norepinephrine, μg/kg/min

0.26+/− 0.35

0.22+/− 0.24

0.30+/− 0.44

0.28+/− 0.50

0.21+/− 0.23

0.37+/− 0.69

0.25+/− 0.51

0.17+/− 0.25

0.34+/− 0.69

  1. Abbreviations used for positive end expiratory pressure (PEEP), tidal volume (TV), arterial partial pressure of carbon dioxide (PaCO2), arterial oxygen saturation (SaO2), horowitz index (PaO2/FIO2), mean arterial pressure (MAP) and central venous pressure (CVP). Data presented as mean ± SD, * p < 0.05 before vs. 2 h, p < 0.05 before vs. 24 h, p < 0.05 alive vs. dead