Table 1 Endothelial glycocalyx protecting agents
Author, reference | Agent | Description |
|---|---|---|
Diebel [60] | Tranexamic acid | Inhibition of endothelial sheddase activation in HUVEC |
Barelli [95] | Fresh frozen plasma | Restoration of endothelial barrier function |
Nelson [40] | Human serum albumin | Faster plasma volume expansion in a rat model of hemorrhagic shock |
Annecke [103] | Sevoflurane | Decreased transudate formation after IR in guinea pig hearts |
Sphingosine-1-phosphate | Protecting endothelial mitochondrial integrity, inhibition of syndecan-1 shedding | |
Astapenko [108] | Regional anaesthesia | Decreased raise in PBR in hip replacement surgery |
Chappell [119] | Hydrocortisone | Attenuation of coronary vessel damage after IR in guinea pig hearts |
Lipowsky [125] | Doxycycline | Inhibition of MMP in rat mesenteric microcirculation |
Carden [126] | L-658758 | Inhibition of elastase in isolated rat lungs after IR |
Lennon [17] | Hyaluronan | Reconstitution of EG |
Broekhuizen [128] | Sulodexide | Reconstitution of EG |
Schmidt [129] | Heparin | Inhibition of heparanase |