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Table 1 Endothelial glycocalyx protecting agents

From: Endothelial glycocalyx in acute care surgery – what anaesthesiologists need to know for clinical practice

Author, referenceAgentDescription
Diebel [60]Tranexamic acidInhibition of endothelial sheddase activation in HUVEC
Barelli [95]Fresh frozen plasmaRestoration of endothelial barrier function
Nelson [40]Human serum albuminFaster plasma volume expansion in a rat model of hemorrhagic shock
Annecke [103]SevofluraneDecreased transudate formation after IR in guinea pig hearts
Alves [81], Zeng [82]Sphingosine-1-phosphateProtecting endothelial mitochondrial integrity, inhibition of syndecan-1 shedding
Astapenko [108]Regional anaesthesiaDecreased raise in PBR in hip replacement surgery
Chappell [119]HydrocortisoneAttenuation of coronary vessel damage after IR in guinea pig hearts
Lipowsky [125]DoxycyclineInhibition of MMP in rat mesenteric microcirculation
Carden [126]L-658758Inhibition of elastase in isolated rat lungs after IR
Lennon [17]HyaluronanReconstitution of EG
Broekhuizen [128]SulodexideReconstitution of EG
Schmidt [129]HeparinInhibition of heparanase