The influence of dexmedetomidine and propofol on circulating cytokine levels in healthy subjects

BMC Anesthesiology

Table 2 Statistically significant ≥10% changes of 10 cytokines in the propofol group

Cytokine	Baseline pg/ml [median (IQR)]	Anesthesia pg/ml [median (IQR)]	Unadjusted p-value	Adjusted p-value
PDGF	2160 (460)	2625 (971)	0.002	0.02
IP-10	332 (188)	289 (112)	0.004	0.03
IL-5	6 (1)	8 (2)	0.006	0.03
IL-7	10 (4)	11 (3)	0.005	0.03
IL-17	158 (60)	175 (71)	0.008	0.03
MIG	245 (81)	201 (69)	< 0.001	0.01
HGF	156 (24)	129 (33)	0.002	0.02
MCP-1	38 (16)	31 (14)	0.004	0.03
CTACK	598 (270)	534 (168)	0.005	0.03
MIF	227 (159)	113 (82)	< 0.001	0.01

Data were analyzed using nonparametric testing due to the skewed distributions and the outlying observations. The median as well as the inter quartile range (IQR) values are reported for each cytokine. The unadjusted p-values were calculated using Wilcoxon signed rank test and the adjusted p-values were calculated using Benjamini-Hochberg method (42 hypothesis tests) controlling for a false discovery rate at 0.05

ISSN: 1471-2253