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Table 2 Differences in creatinine levels and diuresis between patients treated with beta-agonists + levosimendan for low cardiac output syndrome who exhibited kidney failure at diagnosis and evolution of creatinine and diuresis at 24 h, 48 h, and at discharge from the ICU

From: Preservation of renal function in cardiac surgery patients with low cardiac output syndrome: levosimendan vs beta agonists

Inotropic therapy

 

Beta-agonists (n = 15)

Levosimendan (n = 15)

No Kidney failure at Discharge

(n = 9)

Kidney failure at Discharge

(n = 6)

No Kidney failure at Discharge

(n = 15)

Mean +/−SD

Mean +/−SD

Mean +/−SD

Diuresis 24 h before diagnosis of LCOS (ml/kg/h)

0.89+/− 0.38

0.85+/− 0.38

1.66+/−0.38

Diuresis at 24 h. (ml/kg/h)

0.91 +/− 0.30

0.64 +/− 0.23

1.83 +/5.92

Diuresis 48 h. after diagnosis of LCOS (ml/kg/h)

1.09+/− 0.41

0.82 +/− 0.32

2.10+/− 6.26 (p < 0.05)

Baseline creatinine (mg/dl)

1.24 +/−1.68

1.25 +/− 0.82

1.09 +/− 0.82

Creatinine at diagnosis of LCOS (mg/dl)

1.78 +/− 4.57

1.52 +/− 2.56

1.87 +/− 0.24

Creatinine 24 h after diagnosis of LCOS (mg/dl)

1.62 +/− 1.68

2.1 +/−1

1.32+/−3.5

Creatinine 48 h after diagnosis of LCOS (mg/dl)

1.56+/− 3.71

2.72+/− 1*

1.22 +/− 0.53 (p < 0.05)

creatinine levels (mg/dl)

0.97+/− 0.44

2.57 +/− 0.72*

1.21+/− 0.74(p < 0.05)

  1. The patients who were administered levosimendan did not develop kidney failure. In contrast, the incidence of kidney failure at discharge in patients who had renal dysfunction at diagnosis of LCOS who received beta-agonists was 40%
  2. LCOS low cardiac output syndrome