From: Use of sugammadex in patients with neuromuscular disorders: a systematic review of case reports
Author/year | Country | Patient characteristics | Disease | Type of surgery; Duration of surgery | Anesthetic agents | NMBA | NM monitoring | Dose of sugammadex & results of NM monitor | Postoperative course |
---|---|---|---|---|---|---|---|---|---|
Weekes et al., 2010 | Ireland | 38/F; 70 kg | Idiopathic transverse myelitis | Elective cesarean section; 60 min | Thiopentone and rapid sequence induction followed by maintenance with morphine, sevoflurane/oxygen/nitrous oxide; propofol infusion during delayed extubation | Rocuronium 1.2 mg/kg | Qualitative neuromuscular monitoring | Initial neostigmine 5 mg (0.07 mg/kg) & glycopyrollate 1 mg; Pre reversal TOF: four weak TOF twitchesa; Post reversal TOF: 4 weak twitches (for more than 1 h). Sugammadex 4 mg/kg administered (delayed administration because of unavailability) followed by all the clinical signs of adequate recovery in 2 min | Uneventful extubation and recovery |
Staikou and Rekatsina, 2017 | Greece | 31/F; 62 kg; 164 cm; BMI: 23.1 kg/m2 | Multiple sclerosis | Myomectomy; 65 min | Benzodiazepine premedication. Propofol, fentanyl induction followed by maintenance with fentanyl boluses, sevoflurane, nitrous oxide/oxygen | Rocuronium 1 mg/kg for intubation with no further doses | Neuromuscular module of S/5 anaesthesia monitor | Sugammadex 2 mg/kg; Pre reversal TOF count: 3; Post reversal TOF ratio: 0.9 (0.75 min) | Uneventful extubation and recovery. |