Bioelectrical impedance analysis of body composition for the anesthetic induction dose of propofol in older patients

Table 3 Propofol dose until loss of consciousness

Variables	Age < 65 group	Age ≥ 65 group	p-value
Propofol (mg)	90 (40)^a	68.5 (36)^a	0.005
Propofol (mg/kg of TBW)	1.24 (30)^a	1.09 (25)^a	0.05
Time to LOC (min)	2.95 (1.18)^b	2.17 (0.78)^b	0.02
MAP variation^d (mmHg)	19.62 (67)^c	29.04 (54)^c	0.05
Plasma [Propofol] (μg/mL)	3.96 (39)^c	7.68 (34)^c	< 0.001
Time after LOC^e (min)	1.6 (1.3)^b	1.5 (1)^b	0.84
BIS^f	49.5 (22)^a	46 (27)^a	0.88

LOC Loss of consciousness, MAP Mean arterial pressure, TBW Total body weight
^aData are presented as median (CV%)
^bData are presented as mean (SD)
^cData are presented as mean (CV%)
^dVariation = [(MAP before propofol – MAP after propofol)/MAP before propofol]*100
^eTime after LOC is the time when arterial blood sample was obtained after LOC
^fBispectral index value at the time of blood sample collection

ISSN: 1471-2253