Table 3 Post-operative course of primary (total postoperative morphine consumption) and secondary endpoints (complementary analgesia, postoperative complications, ICU and hospital stays)
Variables | OFA group (n = 55) | OA group (n = 55) | OR (CI95%) | P-value |
|---|---|---|---|---|
Total morphine consumption (mg) | 5 (2–18) | 15 (6–34) |  | 0.001 |
Additional analgesic (n, %) | ||||
 Tramadol | 17 (31) | 17 (31) | 1 (0.445–2.245) | 1 |
 Total median dose (mg) | 150 (50–262) | 125 (50–263) |  | 1 |
 Ketoprofen | 10 (18) | 9 (16) | 1.136 (0.422-3.056) | 1 |
 Total median dose (mg) | 100 (50–150) | 100 (50–150) |  | 1 |
 Nefopam | 11 (20) | 7 (13) | 1.714 (0.611–4.812) | 0.441 |
 Total median dose (mg) | 40 (20–100) | 20 (20–33) |  | 0.317 |
Visual analog score | ||||
 Extubation | 0 (0–2) | 0 (0–3) |  | 0.324 |
 12 h after ICU admission | 0 (0–0) | 0 (0–1) |  | 0.777 |
 First postoperative day | 0 (0–2) | 0 (0–2) |  | 0.665 |
 Second postoperative day | 0 (0–2) | 0 (0–2) |  | 0.874 |
Vomiting (n, %) | 5 (9) | 9 (16) | 0.511 (0.160–1.637) | 0.393 |
Creatinine (mmol l−1) | ||||
 at admission to ICU | 83 (72–106) | 76 (64–91) |  | 0.105 |
 on first postoperative day | 80 (66–115) | 77 (69–95) |  | 0.284 |
Troponin Ic (ng ml−1) | ||||
 at admission to ICU | 6.2 (3.7–10) | 7.5 (2.9–20) |  | 0.091 |
 24 h after surgery | 4.7 (2.6–8.2) | 7 (3.1–16) |  | 0.091 |
PaO2 | ||||
 at admission to ICU | 162 (113–195) | 155 (114–181) |  | 0.479 |
 24 h after surgery | 99 (83–122) | 115 (89–138) |  | 0.084 |
FiO2 | ||||
 at admission to ICU | 50 (30–60) | 50 (50–60) |  | 0.005 |
 24 h after surgery | 28 (25–32) | 32 (30–36) |  | 0.018 |
PaO2/FiO2 ratio | ||||
 at admission to ICU | 357 (275–458) | 290 (213-372) |  | 0.006 |
 24 h after surgery | 355 (261–420) | 322 (265–435) |  | 0.919 |
Time to extubation (hours) | 3 (1–5) | 5 (3–6) |  | 0.001 |
Catecholamine use, n (%) | ||||
 Norepinephrine | 26 (32) | 31 (38) | 0.694 (0.328–1.471) | 0.447 |
 Dobutamine | 9 (16) | 9 (16) | 0.766 (0.277–2.115) | 0.798 |
Transfusion, n (%) | ||||
 Red blood cell | 16 (29) | 18 (33) | 0.843 (0.375–1.895) | 0.837 |
Endpoint composite score, n (%) | 25 (43) | 38 (66) | 0.373 (0.171–0.813) | 0.021 |
 Confusion | 4 (7) | 10 (19) | 0.353 (0.103–1.204) | 0.151 |
 Stroke | 1 (2) | 0 |  | 1 |
 Seizure | 1 (2) | 0 | 1 | |
 Atrial fibrillation, | 15 (27) | 22 (40) | 0.563 (0.252–1.254) | 0.228 |
 Ventricular tachycardia or fibrillation | 1 (2) | 3 (5) | 0.315 (0.032–3.125) | 0.599 |
 Atrio-ventricular block requiring pacemaker implantation | 2 (4) | 1 (2) | 2.038 (0.179–23.151) | 1 |
 Acute renal failure | 12 (22) | 14 (26) | 0.817 (0.338–1.974) | 0.823 |
 Reintubation | 1 (2) | 3 (6) | 0.321 (0.032–3.186) | 0.612 |
 Non-invasive ventilation | 15 (27) | 27 (49) | 0.389 (0.176–0.861) | 0.032 |
 Mortality | 1 (2) | 1 (2) | 1 (0.061—16.401) | 1 |
ICU stays (days) | 2 (1–3) | 3 (2–5) |  | 0.037 |
Hospital stays (days) | 8 (7–15) | 10 (8–14) | 0.790 | |