Fig. 6

Influence of HDAC2 KD on pain behavior and inflammatory cytokine production of CIVP rats. a HDAC2 expressions were examined in spinal cord tissues of WT and HDAC2 KD rats with CIVP. b The post-treatment AWR figures. c MWT following DEX treatment. d TWL scores following DEX treatment of CIVP with different treatment. At 30 min after acetic acid was injected, we collected peripheral blood from the animals, and (E) the serum mRNA levels of IL-6, TNF-α, and IL-1β were determined by Q-PCR after DEX administration and adenovirus infection. Mean ± standard deviation (N = 3) was used to describe the data. *P < 0.05, ***P < 0.001, compared to the indicated group. ^#P < 0.05, compared to same treated group of WT rats. Abbreviations: AWL, abdominal withdrawal reflex; CIVP, chronic inflammatory visceral pain; DEX, dexmedetomidine; KD, knock down; miRNA, micro ribonucleic acid; MWT, mechanical withdrawal threshold; Q-PCR, quantitative polymerase chain reaction; TWL, thermal withdrawal latency; and WT, wild type