Fig. 4
From: MiR-34a affects dexmedetomidine-inhibited chronic inflammatory visceral pain by targeting to HDAC2
The effect of intrathecal injection of adenovirus-miR-34a inhibitor on pain behaviors of CIVP rats. At 2 weeks after induction with TNBS, spinal cords were isolated from rats with intrathecal injection of adenovirus-miR-34a inhibitor or adenovirus-NC inhibitor. a Q-PCR was used to determine the levels of miR-34a in spinal cord tissues. b, c, d MWT, AWR, and TWL scores following DEX treatment and intrathecal injection. Mean ± standard deviation (N = 3) was used to describe the data. *P < 0.05, **P < 0.01, ***P < 0.001, compared to the normal group or the indicated group. Abbreviations: AWL, abdominal withdrawal reflex; CIVP, chronic inflammatory visceral pain; DEX, dexmedetomidine; miRNA, micro ribonucleic acid; MWT, mechanical withdrawal threshold; Q-PCR, quantitative polymerase chain reaction; TNBS, 2,4,6-Trinitrobenzenesulfonic acid; and TWL, thermal withdrawal latency