Fig. 1
From: MiR-34a affects dexmedetomidine-inhibited chronic inflammatory visceral pain by targeting to HDAC2
The antinociceptive and anti-inflammatory effects of DEX administration in the TNBS-induced CIVP rat models. a AWR figures after DEX treatment for CIVP rat models. b MWT following DEX treatment. c TWL scores following DEX treatment. d Spinal cord was collected from the rats after administration of TNBS. Tissues were then homogenized for IL-1β, IL-6, and TNF-α quantification at mRNA levels via Q-PCR. The results of the three separate tests were recorded as mean ± standard deviation. N = 3. *P < 0.05, **P < 0.01, ***P < 0.001, compared to the normal group or the indicated group. Abbreviations: AWL, abdominal withdrawal reflex; CIVP, chronic inflammatory visceral pain; DEX, dexmedetomidine; miRNA, micro ribonucleic acid; MWT, mechanical withdrawal threshold; Q-PCR, quantitative polymerase chain reaction; TNBS, 2,4,6-Trinitrobenzenesulfonic acid; and TWL, thermal withdrawal latency