Table 2 Characteristics of intervention and outcomes
Study ID | Dexamethas one doses | Control | Time of intervention or control | POCD/POD assessment method | POCD/POD definition | Assessment time |
|---|---|---|---|---|---|---|
Fang 2014 | D1:0.1 mg/kg D2:0.2 mg/kg | NS | before induction of anesthesia | Neuro-Psychologic-al test battery | An individual whose postoperative performance deteriorated by 1 or more SDs on 2 or more tests was classified as having experienced early POCD. | the day before and On the fifth postoperativ-e day |
Glumac 2017 | 0.1 mg/kg | NS | 10 h before the surgery | a battery of five neuropsychological tests | Authous calculated the Jacobson and Truax Reliable Change Index (RCI) for each patient in the dexamethasone and placebo groups. POCD in an individual is defined as an RCI equal to or less than S1.96 on at least one test | on the 6th day after the surgical procedure |
Mardani 2013 | 8 mg DEX intravenous before induction of anesthesia followed by 8 mg every 8 h for 3 day. | NS | before induction of anesthesia followed every 8 h for 3 day | MMSE | delirium disorder was diagnosed if DSM-IV criteria were met in a patient | Preoperative day (PROD), first, second, andthird postoperativ-e day. |
Ottens 2014 | 1 mg/kg (maximum 100 mg) | NS | shortly after induction of general anesthesia | a battery of five neuropsychological tests | Authous calculated the Jacobson and Truax Reliable Change Index (RCI), they defined POCD in an individual patient as an RCI equal to or less than −1.96, or Z-score equal to or less than − 1.96 in at least two different tests. | 1 day before surgery and 1 month and 12 months after surgery |
Sauer 2014 | 1 mg/kg (maximum 100 mg) | NS | at the time of induction of anesthesia | CAM-ICU | POD: diagnosed by the Confusion Assessment Method (CAM) adapted for the ICU (CAM-ICU) . | The primary study outcome was the presence of delirium on any of the first 4 postoperativ-e days. 7 days a week at a fixed time point |