Table 1 Gas exchange data
CTRL | INJURED | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
PEEP6 | PEEP9 | PEEP6 | ||||||||
I:E ratio | 1:2 | 1:1 | 2:1 | 1:2 | 1:1 | 2:1 | 1:2 | 1:1 | 2:1 | |
Artery | pH | 7.459 ±0.02 | 7.467 ±0.03 | 7.454 ±0.02 | 7.244$ ±0.03 | 7.253$ ±0.04 | 7.269$ ±0.04 | 7.202$ ±0.04 | 7.221$ ±0.02 | 7.218$ ±0.02 |
PaCO2 (mmHg) | 35.1 ±1.54 | 34.1 ±1.24 | 34.0 ±1.60 | 49.2$ ±2.15 | 46.9$ ±2.18 | 44.0*$ ±1.39 | 54.3$& ±3.47 | 49.7$& ±2.21 | 50.3$& ±2.99 | |
PaO2 (mmHg) | 189.6 ±2.78 | 192.6 ±2.93 | 193 ±4.21 | 78.8$ ±16.1 | 119.9$ ±29.7 | 153.1*$ ±37.0 | 42.0$& ±2.67 | 50.9$& ±3.51 | 53.9*$& ±5.82 | |
PaO2/FIO2 | 474.1 ±6.96 | 481.6 ±7.32 | 482.5 ±10.5 | 87.5$ ±17.9 | 133.2$ ±33.0 | 170.1*$ ±41.1 | 46.7$& ±2.96 | 56.5$& ±3.91 | 59.9$& ±6.47 | |
HCO3−(mmol/l) | 24.9 ±0.68 | 24.7 ±1.04 | 23.8 ±0.80 | 21.2$ ±0.54 | 20.8$ ±1.2 | 20.4$ ±1.2 | 21.2$ ±1.0 | 20.3$ ±0.5 | 20.3$ ±0.6 | |
BE (mmol/l) | 1.0 ±0.93 | 0.89 ±1.42 | −0.13 ±1.10 | −6.4$ ±0.98 | −6.4$ ±1.7 | − 6.5$ ±1.8 | −6.9$ ±1.6 | − 7.3$ ±0.75 | −7.5$ ±0.50 | |
SaO2 (%) | 100.0 ±0.0 | 100 ±0.0 | 100 ±0.0 | 85.1$ ±4.2 | 90.0$ ±4.3 | 93.1$ ±3.4 | 63.9$& ±5.4 | 75.0$& ±4.4 | 75.9$& ±4.8 | |
Lac (mmol/l) | 2.67 ±0.44 | 2.61 ±0.43 | 3.07 ±0.50 | 4.98 ±1.0 | 5.03 ±1.1 | 5.71 ±1.1 | 6.36$ ±1.2 | 5.9$ ±0.80 | 5.9$ ±0.45 | |
Vein | pH | 7.406 ±0.016 | 7.412 ±0.02 | 7.400 ±0.02 | 7.227$ ±0.03 | 7.232$ ±0.04 | 7.238$ ±0.03 | 7.191$ ±0.04 | 7.197$ ±0.02 | 7.225$ ±0.01 |
PvCO2 (mmHg) | 38.5 ±2.0 | 38.2 ±1.83 | 39.9 ±1.85 | 53.7$ ±2.80 | 47.7$ ±2.8 | 49.5$ ±2.9 | 56.0$ ±4.7 | 54.8$& ±2.3 | 52.1$ ±2.6 | |
PvO2 (mmHg) | 37.5 ±2.3 | 36.3 ±1.86 | 31.8* ±2.49 | 39.4 ±2.71 | 42.3 ±2.79 | 40.9$ ±2.92 | 32.0$ ±2.5 | 35.3& ± 2.5 | 35.7& ± 2.8 | |
HCO3−(mmol/l) | 24.09 ±1.0 | 24.38 ±1.3 | 24.5 ±1.1 | 22.2$ ±0.5 | 20.3$ ±1.5 | 21.0$ ±0.96 | 21.1$ ±1.0 | 21.2$ ±0.61 | 21.5$ ±1.0 | |
BE (mmol/l) | −0.50 ±1.0 | −0.25 ±1.5 | −0.5 ±1.3 | −5.5$ ±0.8 | −7.1$ ±2.1 | −6.4$ ±5.8 | −7.1$ ±1.5 | −7.0$ ±0.9 | −6.1$ ±1.1 | |
SvO2 (%) | 70.4 ±4.2 | 69.4 ±2.9 | 59.5* ±4.3 | 61.4 ±5.4 | 66.0 ±4.7 | 64.6 ±5.8 | 46.8$& ±6.1 | 52.8$& ±5.6 | 56.0$& ±4.8 | |
Lac (mmol/l) | 8.41 ±0.31 | 8.37 ±0.33 | 8.19 ±0.28 | 8.16 ±0.28 | 7.63 ±0.64 | 7.93 ±0.31 | 7.71 ±0.33 | 8.16 ±0.31 | 8.27 ±0.56 | |
C(a-v)O2 (ml/dl) | 3.82 ±0.57 | 3.91 ±0.22 | 4.98* ±0.50 | 2.79$ ±0.31 | 2.66$ ±0.33 | 3.49*$ ±0.31 | 1.84$& ±0.25 | 2.53$ ±0.27 | 2.73*$ ±0.48 | |
Brain \( \dot{Q} \) O2 (ml/min) | 2.05 ±0.24 | 1.82 ±0.19 | 1.22* ±0.24 | 1.95 ±0.17 | 1.82 ±0.25 | 1.84$ ±0.22 | 1.71 ±0.21 | 2.36* ±0.31 | 2.28*$ ±0.40 | |