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Table 1 Baseline characteristics of adults patients admitted to the ICU during 2012–2017

From: Association between fluctuations in serum chloride levels and 30-day mortality among critically ill patients: a retrospective analysis

Variable

Total (18,825)

Mean

SD

Sex: male

10,839 (57.6%)

  

Age, years

 

63.7

16.0

Body mass index, kg m−2

 

23.6

3.9

APACHE II

 

20.3

9.8

Comorbidities at ICU admission

 Hypertension

8160 (43.3%)

  

 Diabetes mellitus

1673 (8.9%)

  

 Ischemic heart disease

447 (2.4%)

  

 Cerebrovascular disease

856 (4.5%)

  

 Chronic obstructive lung disease

836 (4.4%)

  

 Liver disease (LC, hepatitis, fatty liver)

603 (3.2%)

  

 Dyslipidemia

1191 (6.3%)

  

 Chronic kidney disease

3236 (17.2%)

  

 Anemia (Hb < 10 g dl−1)

6919 (36.8%)

  

 Cancer

4001 (21.3%)

  

Characteristics of ICU admission

 Admission through emergency department

10,950 (58.2%)

  

 Admitting department

  Internal medicine

3851 (20.5%)

  

  Neurologic center

4770 (25.3%)

  

  Post-cardiothoracic surgery

5765 (30.6%)

  

  Post-other surgery

4438 (23.6%)

  

 Length of ICU stay, day

 

3.4

10.6

 Length of hospital stay, day

 

13.8

20.8

 pRBC transfusion within 72 h after ICU adm

8294 (44.1%)

  

 RRT within 72 h after ICU adm

458 (2.4%)

  

 Vasopressor infusion within 72 h after ICU adm

3433 (18.2%)

  

aCumulative fluid balance within 72 h after ICU adm

 

3.2%

4.7%

  Negative (< 0%)

3933 (20.9%)

  

  Even (0–5%)

9680 (51.4%)

  

  Positive, Mild to moderate (5–10%)

3889 (20.7%)

  

  Positive, Severe (> 10%)

1323 (7.0%)

  

 Fluid administration for 72 h after ICU admission

  NaCl 0.9%, ml

 

1729.1

2097.8

  Balanced crystalloid, ml

 

521.9

871.2

  Hydroxyethyl starch, ml

 

78.3

249.8

Serum chloride (Cl) in ICU, mmol L− 1

 The number of measurements for 72 h after ICU adm

 

3.3

0.9

 Cl on ICU admission (baseline Cl)

 

103.7

5.6

  Normochloremia on ICU adm (97–110 mmol L−1)

11,861 (63.0%)

  

  Hypochloremia on ICU adm (< 97 mmol L− 1)

1753 (9.3%)

  

  Hyperchloremia on ICU adm (> 110 mmol L− 1)

5211 (27.7%)

  

 Maximum Cl within 72 h after ICU adm

 

107.8

5.7

 Minimum Cl within 72 h after ICU adm

 

100.8

5.1

bPositive fluctuation of Cl for 72 h after ICU adm

 

4.1

4.1

   > 10 mmol L−1

1243 (6.6%)

  

cNegative fluctuation of Cl for 72 h after ICU adm

 

2.9

3.5

   > 10 mmol L−1

682 (3.6%)

  

30-day mortality after ICU admission

1011 (5.1%)

  
  1. ICU intensive care unit, APACHE Acute Physiology and Chronic Health Evaluation, adm admission, LC liver cirrhosis, Hb hemoglobin, pRBC packed red blood cells, RRT renal replacement therapy
  2. aCumulative fluid balance: (Total input fluid – total output fluid, L) × 100 x weight in admission (kg)−1
  3. bPositive fluctuation in Cl: (Maximum Cl – Preadmission Cl) for 72 h after ICU admission
  4. cNegative fluctuation in Cl: (Preadmission Cl – Minimum Cl) for 72 h after ICU admission