The effect of magnesium on the reversal of rocuronium-induced neuromuscular block with sugammadex: an ex vivo laboratory study

Table 1 Best fit values of concentration-response curves for rocuronium and sugammadex

Curve	Mean (95% CI) EC₅₀	Mean (95% CI) EC₉₅
Magnesium	4.06 (3.91–4.21) mM
Rocuronium ([Mg²⁺] = 1 mM)	7.50 (6.93–8.12) μM	12.89 (10.67–15.56) μM
Rocuronium ([Mg²⁺] = 1.5 mM)	4.26 (4.09–4.43) μM	7.35 (6.64–8.13) μM
Rocuronium ([Mg²⁺] = 1.5 mM)	p < 0.0001	p < 0.0001
Sugammadex (Rocuronium 0.5 mg, [Mg²⁺] = 1 mM)	3.67 (3.43–3.92) μM	7.22 (6.09–8.54) μM
Sugammadex (Rocuronium 0.3 mg, [Mg²⁺] = 1.5 mM)	1.51 (1.42–1.60) μM	4.48 (3.80–5.29) μM
Sugammadex (Rocuronium 0.3 mg, [Mg²⁺] = 1.5 mM)	p < 0.0001	p < 0.002
Sugammadex (Rocuronium 0.5 mg, [Mg²⁺] = 1 + 0.5 mM)	5.36 (5.18–5.53) μM	7.61 (7.05–8.20) μM
Sugammadex (Rocuronium 0.5 mg, [Mg²⁺] = 1 + 0.5 mM)	p < 0.0001	p = 0.542

The displayed p-values are in comparison with the reference concentration-response curve measured with [Mg²⁺] = 1 mM. EC₅₀: effective concentration for 50% effect, EC₉₅: effective concentration for 95% effect, CI: confidence interval

ISSN: 1471-2253