Fig. 5

Effect of post-block administration of magnesium on the concentration-response curve of sugammadex for reversing rocuronium-induced block. Normalized contraction force amplitude as a function of sugammadex concentration on a logarithmic scale (logarithm to base 10). After an initial dose of 0.5 mg rocuronium at [Mg2+] = 1 mM, the block was reversed by sugammadex at either unchanged magnesium concentration (○) or by increasing [Mg2+] to 1.5 mM after partial reversal (■). Magnesium concentration was only increased after partial reversal (indicated by black arrow) to be able to visualize contractions despite potentiation of the block by magnesium. The black dashed line (⁃⁃⁃) shows actual normalized contraction force amplitude, whereas the grey dotted line (● ● ●) is the best fit curve calculated from measurements on n = 5 different specimens by non-linear regression. Measurement points represent mean values of normalized contraction force amplitude at a given concentration. Error bars show the standard deviation of measurement points