Fig. 4

The concentration-response curve of sugammadex for reversing rocuronium-induced block at pre-block magnesium concentrations of 1 and 1.5 mM. Normalized contraction force amplitude as a function of sugammadex concentration on a logarithmic scale (logarithm to base 10). Due to potentiation of neuromuscular block by magnesium, dose of rocuronium for achieving block was either 0.3 mg ([Mg2+] = 1.5 mM) or 0.5 mg ([Mg2+] = 1 mM). The curve is the best fit curve calculated from measurements on n = 5 different specimens by non-linear regression. Measurement points represent mean values of normalized contraction force amplitude at a given concentration. Error bars show the standard deviation of measurement points