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Table 3 Characteristics of patients with positive SF/BC result compared to those with negative SF/BC results

From: Multiplex polymerase chain reaction to diagnose bloodstream infections in patients after cardiothoracic surgery

 

PCR (SeptiFast)

Blood culture

 

Negative (n = 237)

Positive (n = 42)

P-value

Negative (n = 232)

Positive (n = 47)

P-value

Age [years]

68.0 [64.3–70.0]

57 [51.7–68.0]

0.010

67 [62.0–69.0]

69 [59–69]

n.s.

Male Gender [n, %]

161 (68)

30 (71)

n.s.

163 (70)

28 (59)

n.s.

Operative Procedure [n, %]

 CABG

47 (20)

9 (21)

n.s.

46 (20)

10 (21)

n.s.

 Isolated AVR

8 (3)

1 (2)

n.s.

9 (4)

0 (0)

n.s.

 Isolated MVS

5 (2)

1 (2)

n.s.

4 (2)

2 (4)

n.s.

 Combined procedures

101 (43)

14 (33)

n.s.

99 (43)

16 (34)

n.s.

 Aortic surgery

25 (11)

4 (10)

n.s.

24 (10)

5 (11)

n.s.

 Thoracic transplant

13 (5)

4 (10)

n.s.

11 (5)

6 (13)

n.s.

 Others

38 (16)

9 (21)

n.s.

37 (16)

8 (17)

n.s.

CPB time [min.]

177.0 [147.6–186.4]

149.0 [116.6–207.8]

n.s.

174.5 [147.2–185.0]

161.0 [139.7–198.9]

n.s.

Euro-Score II [%]

7.0 [5.2–10.1]

8.8 [2.9–21.0]

n.s.

 

10.5 [5.4–21.6]

n.s.

TISS-28 on day of SF/BC

19 [17–21]

21 [15–22]

n.s.

19 [17–21]

18 [14–21]

n.s.

SAPS on day of SF/BC

32 [31–34]

30 [27–35]

n.s.

32 [31–33]

31 [25–33]

n.s.

Oxygenation [mmHg/FiO2]

216.0 [196.3–230.4]

240.0 [210.2–269.5]

n.s.

220 [210.8–235.0]

214.5 [195.7–282.7]

n.s.

Heart frequency [min−1]

80.0 [80.0–90.0]

90.0 [83.4–106.6]

n.s.

90.0 [80.0–90.0]

90 [90.0–100.0]

n.s.

Body temperature [°C]

37.6 [37.4–37.8]

37.6 [37.1–37.9]

n.s.

37.6 [37.4–37.8]

37.6 [37.1–38.0]

n.s.

RRT [n, %]

125 (53)

31 (74)

0.01

129 (56)

27 (57)

n.s.

Laboratory values

 Serum lactate [mg/dl]

1.5 [1.4–1.8]

1.4 [1.1–1.9]

n.s.

1.5 [1.4–1.7]

1.4 [1.1–2.5]

n.s.

 Bilirubin [mg/dl]

0.9 [0.7–1.0]

1.0 [0.8–1.6]

n.s.

0.9 [0.7–1.0]

0.9 [0.5–1.2]

n.s.

 Leucocytes [/nl]

14.0 [13.0–15.0]

12 [10.3–15.0]

0.014

14.0 [13.0–14.0]

14.0 [10.5–16.0]

n.s.

 Fibrinogen [mg/dl]

464.0 [430.0–496.7]

525.0 [389.9–594.2]

n.s.

472 [433.8–503.9]

504 [438.5–544.9]

n.s.

 CRP [mg/dl]

14.4 [13.3–15.4]

14.5 [13.3–15.4]

0.009

14.8 [13.7–15.9]

15.2 [13.2–19.7]

n.s.

 PCT [ng/ml]

3.1 [2.3–4.7]

6.6 [2.7–16.4]

0.015

3.4 [2.5–4.9]

2.2 [1.3–3.8]

n.s.

 IL-6 [pg/ml]

72.3 [46.5–104.7]

235.0 [83.5–1582.2]

0.010

90.9 [61.7–144.3]

141.0 [46.6–240.2]

n.s.

ICU stay [days]

16 [15–19]

22 [16–33]

0.019

16 [15–19]

18.5 [14.0–26.2]

0.044

Hospital stay [days]

23 [19–29]

38 [25–59]

n.s.

27 [21–30]

28 [20.7–42.7]

n.s.

  1. AVR Aortic valve replacement, CABG coronary artery bypass grafting, CPB Cardiopulmonary bypass, CRP C-reactive protein, ICU intensive care unit, IL-6 interleukin 6, LTX lung transplant, MVS mitral valve surgery, n.s. not significant (p > 0.05), PCT procalcitonin, POD postoperative day, RRT renal replacement therapy, SAP Simplified Acute Physiology Score, TISS Therapeutic Intervention Scoring System, TVS tricuspid valve surgery
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BMC Anesthesiology

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