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Table 3 Course of coagulation parameters platelet count, aPTT, PT, fibrinogen, CT (Intem), CT (Extem), MCF (Fibtem), TRAP, ASPI, and ADP

From: Why does a point of care guided transfusion algorithm not improve blood loss and transfusion practice in patients undergoing high-risk cardiac surgery? A prospective randomized controlled pilot study

 

Conventional group

(n = 14)

PoC group

(n = 11)

P

Platelet count [/nl]

 Screening

241 (207–276)

225 (201–272)

0.647

 Admission to ICU

153 (111–184)

150 (120–191)

0.893

 24 h postoperatively

154 (130–176)

139 (127–167)

0.979

aPTT [s]

 Pre-operatively

33.4 (31.8–38.8)

33.9 (33.3–38.5)

0.403

 Admission to ICU

35.2 (33.4–37.3)

38.1 (37.3–40.9)

0.038*

 24 h postoperatively

34.6 (32.4–37.9)

38.1 (34.5–43.3)

0.044*

Thromboplastin time [%]

 Pre-operatively

98 (88–104)

96 (82–101)

0.373

 Admission to ICU

57 (55–65)

60 (54–62)

0.851

 24 h postoperatively

77 (65–81)

67 (58–82)

0.222

Fibrinogen [g/l]

 Pre-operatively

3.98 (3.5–4.66)

3.60 (3.37–4.83)

0.467

 Admission to ICU

2.58 (2.17–3.42)

2.48 (2.09–3.07)

0.699

 24 h postoperatively

3.85 (3.51–4.06)

3.74 (3.53–4.5)

0.786

CT (Intem) [s]

 Pre-operatively

152 (131–179)

164 (151–185)

0.344

 Admission to ICU

188 (179–201)

195 (177–213)

0.536

 24 h postoperatively

157 (143–170)

166 (148–179)

0.202

CT (Extem) [s]

 Pre-operatively

52 (48–57)

60 (51–62)

0.149

 Admission to ICU

64 (56–71)

66 (59–75)

0.291

 24 h postoperatively

55 (48–63)

53 (46–64)

0.767

MCF (Fibtem) [mm]

 Pre-operatively

23 (21–25)

22 (19–24)

0.572

 Admission to ICU

15 (13–20)

15 (12–21)

0.809

 24 h postoperatively

22 (20–25)

24 (20–28)

0.424

TRAP [AU]

 Pre-operatively

119 (82–159)

103 (93–143)

0.501

 Admission to ICU

139 (93–159)

116 (85–149)

0.572

 24 h postoperatively

147 (116–157)

134 (129–158)

0.647

ASPI [AU]

 Pre-operatively

20 (13–43)

10 (7–30)

0.183

 Admission to ICU

20 (12–48)

24 (5–52)

0.893

 24 h postoperatively

33 (19–48)

34 (23–41)

0.767

ADP [AU]

 Pre-operatively

64 (43–78)

63 (35–71)

0.434

 Admission to ICU

61 (44–72)

45 (33–82)

0.476

 24 h postoperatively

71 (53–85)

71 (58–90)

0.727

  1. Results are given as median (IQR). Reference ranges of the local laboratory: Platelets 150–370/nl; aPTT 26–40s; thromboplastin time 70–130%; fibrinogen 1.6–4.0 g/l. Reference ranges for activated rotational thromboelastometry: CT (Intem) 137–246 s; CT (Extem) 42–74 s; MCF (Fibtem) 9-25 mm. Reference ranges for multiple aggregometry: TRAP 84–128 AU; ASPI 71–115 AU; ADP 57–113 AU. Differences were analysed using nonparametric Mann-Whitney U test for two independent samples with α = 0.05 (two-sided). Significant tests are marked with *