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Table 2 Intraoperative regional cerebral oxygen saturation with bupivacaine and levobupivacaine

From: Effects of bupivacaine or levobupivacaine on cerebral oxygenation during spinal anesthesia in elderly patients undergoing orthopedic surgery for hip fracture: a randomized controlled trial

 

All patients

Patients with any desaturation

B

LB

 

B

LB

 

Desaturation > 20% below baseline

 Left hemisphere

(n = 28)

(n = 28)

 

(n = 9)

(n = 12)

 

  AUC (min %)

14.93 (42.60)

12.43 (30.86)

ns

69.67 (72.28)

34.80 (44.63)

ns

  Time below 20% from baseline (min)

5.57 (14.47)

5.21 (13.14)

ns

17.36 (21.84)

12.14 (18.21)

ns

  % of time with desaturation

6.07 (17.47)

4.82 (11.40)

ns

18.9 (27.52)

11.25 (15.49)

ns

  Time to first deep (min)

ns

23.67 (22.31)

32.66 (30.27)

ns

 Right hemisphere

(n = 28)

(n = 28)

ns

(n = 9)

(n = 10)

ns

  AUC (min %)

14.32 (35.34)

4.32 (14.98)

ns

57.29 (52.43)

15.3 (26.05)

ns

  Time below 20% from baseline (min)

4.74 (11.87)

2.44 (8.30)

ns

14.75 (17.58)

6.84 (13.15)

ns

  % of time with desaturation

4.01 (9.33)

2.16 (7.08)

ns

14.02 (13.24)

6.04 (11.15)

ns

  Time to first deep (min)

29.28 (25.65)

45.97 (22.56)

ns

Desaturation < 50% (absolute values)

 Left hemisphere

(n = 28)

(n = 28)

 

(n = 15)

(n = 13)

 

  AUC (min %)

53.07 (108.82)

158.29 (440.69)

ns

114.31 (138.06)

340.92 (607.88)

ns

  Time below 20% from baseline (min)

12.82 (24.37)

16.59 (36.85)

ns

23.93 (29.32)

35.75 (48.11)

ns

  % of time with desaturation

11.62 (19.38)

13.65 (30.69)

ns

21.68 (22.24)

29.41 (40.20)

ns

  Time to first deep (min)

ns

20.71 (30.77)

30.57 (35.09)

ns

 Right hemisphere

(n = 28)

(n = 28)

ns

(n = 17)

(n = 13)

ns

  AUC (min %)

77.54 (152.84)

134.14 (422.71)

ns

127.71 (180.6)

288.9 (594.63)

ns

  Time below 20% from baseline (min)

15.84 (30.14)

13.32 (31.68)

ns

26.09 (35.34)

28.68 (42.20)

ns

  % of time with desaturation

13.08 (23.03)

11.12 (26.55)

ns

21.54 (26,49)

23.94 (35.40)

ns

  Time to first deep (min)

28.80 (34.42)

19.12 (27.98)

ns

Lowest values rCSO2 (%)

 

(n = 28)

(n = 28)

    

 Left hemisphere

49.46 (8.59)

48.32 (11.71)

ns

 Right hemisphere

48.18 (10.60)

49.86 (11.87)

ns

  1. B Bupivacaine, LB Levobupivacaine, AUC area under the curve, rCSO2 regional cerebral oxygen saturation, ns not significant p value. Values expressed as mean (Standard Deviation) for all patients of the treatment group and for patients who presented desaturation of the measured hemisphere