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Fig. 3 | BMC Anesthesiology

Fig. 3

From: Sevoflurane preconditioning induces tolerance to brain ischemia partially via inhibiting thioredoxin-1 nitration

Fig. 3

Nitrated hTRX-1 reversed neuroprotection induced by sevoflurane preconditioning. The administration of 3-N-Trx-1 enlarged brain infarct volume a, c, deteriorated the neurological results b, and aggravated apoptosis in Sev MCAO group d, e. Nitrated hTrx-1 was harvested in vitro by incubating Sin-1 with hTrx-1 and confirmed by western blotting after ultrafiltration f. Sin-1 almost completely inactivated the activity of Trx-1 g. *P<0.05 vs. Oxy MCAO, #P < 0.05 vs. Sev MCAO, △P < 0.05 vs. 3-N-Trx-1. Bar = 50 μm

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BMC Anesthesiology

ISSN: 1471-2253

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